Metaxalone and Zonegran drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Metaxalone (metaxalone) and Zonegran (zonisamide). Common drug interactions include multiple sclerosis relapse among females and back injury among males.

The phase IV clinical study analyzes what interactions people have when they take Metaxalone and Zonegran. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Metaxalone?

Metaxalone has active ingredients of metaxalone. It is often used in back pain. eHealthMe is studying from 4,452 Metaxalone users. Check the latest studies of Metaxalone.

What is Zonegran?

Zonegran has active ingredients of zonisamide. It is often used in epilepsy. eHealthMe is studying from 6,211 Zonegran users. Check the latest studies of Zonegran.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

13 people who take Metaxalone and Zonegran together, and have interactions are studied.

Metaxalone and Zonegran drug interactions.

What are the common drug interactions of Metaxalone and Zonegran, by gender? *:

female:

Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Sensory disturbance (sense disturbance)
Skin burning sensation
Blood cholesterol increased
Head injury
Hypertonic bladder (bladder-storage function that causes a sudden urge to urinate)
Weight decreased
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Flushing (the warm, red condition of human skin)
Pain in extremity

male:

Back injury
Headache (pain in head)
Insomnia (sleeplessness)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)

What are the common drug interactions of Metaxalone and Zonegran, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Back injury
Headache (pain in head)
Insomnia (sleeplessness)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)

30-39:

n/a

40-49:

n/a

50-59:

Contusion (a type of hematoma of tissue in which capillaries)
Skin burning sensation
Fall

60+:

Fall
Head injury
Hypertonic bladder (bladder-storage function that causes a sudden urge to urinate)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 8 people, 61.54%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 5 people, 38.46%
Headache (pain in head): 3 people, 23.08%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 2 people, 15.38%
Drowsiness: 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

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