Metformin and Anzemet drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Metformin (metformin hydrochloride) and Anzemet (dolasetron mesylate). Common drug interactions include back pain among females and pleural effusion among males.
The phase IV clinical study analyzes what interactions people have when they take Metformin and Anzemet. It is created by eHealthMe based on reports of 38 people who take the same drugs from the FDA, and is updated regularly.
What is Metformin?
Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 465,354 Metformin users. Check the latest studies of Metformin.
What is Anzemet?
Anzemet has active ingredients of dolasetron mesylate. eHealthMe is studying from 2,603 Anzemet users. Check the latest studies of Anzemet.
38 people who take Metformin and Anzemet together, and have interactions are studied.

What are the common drug interactions of Metformin and Anzemet, by gender? *:
female:
- Back pain
- Blood alkaline phosphatase increased
- Bone disorder
- Conjunctivitis (pink eye)
- Depression
- Encephalopathy (functioning of the brain is affected by some agent or condition)
- Fall
- Foot fracture
- Gingival erosion (gum ulcer)
- Haematocrit decreased
male:
- Pleural effusion (water on the lungs)
- Renal failure acute (rapid kidney dysfunction)
- Hypokalaemia (low potassium)
- Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood)
- Hypophosphataemia (electrolyte disturbance in which there is an abnormally low level of phosphate in the blood)
- Lymphadenopathy (disease or enlargement of lymph nodes)
- Lymphatic obstruction (blockage in lymphatic duct)
- Pulmonary embolism (blockage of the main artery of the lung)
- Pyrexia (fever)
- Anaemia (lack of blood)
What are the common drug interactions of Metformin and Anzemet, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
n/a
10-19:
n/a
20-29:
n/a
30-39:
n/a
40-49:
- Cellulitis (infection under the skin)
- Conjunctivitis (pink eye)
- Encephalopathy (functioning of the brain is affected by some agent or condition)
- Foot fracture
- Gingival erosion (gum ulcer)
- Haematocrit decreased
- Haemoglobin decreased
- Headache (pain in head)
- Hordeolum (small collection of pus (abscess) on the eyelid)
- Hyperglycaemia (high blood sugar)
50-59:
- Coagulopathy (blood's ability to clot is impaired)
- Haemorrhage (bleeding)
- Hepatic failure (liver failure)
- Hypotension (abnormally low blood pressure)
- Hypoxia (low oxygen in tissues)
- Intestinal ischaemia (decreased supply of oxygenated blood to the intestines)
- Multi-organ failure (multisystem organ failure)
- Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
- Pyrexia (fever)
- Renal failure acute (rapid kidney dysfunction)
60+:
- Pleural effusion (water on the lungs)
- Pulmonary embolism (blockage of the main artery of the lung)
- Lymphatic obstruction (blockage in lymphatic duct)
- Renal failure acute (rapid kidney dysfunction)
- Sepsis (a severe blood infection that can lead to organ failure and death)
- Thrombocytopenia (decrease of platelets in blood)
- Anaemia (lack of blood)
- Ascites (accumulation of fluid in the abdominal cavity)
- Dyspnoea (difficult or laboured respiration)
- Pain
What are the existing conditions these people have? *
- Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 5 people, 13.16%
- Anaemia (lack of blood): 4 people, 10.53%
- Nausea (feeling of having an urge to vomit): 4 people, 10.53%
- Indigestion: 4 people, 10.53%
- High Blood Pressure: 3 people, 7.89%
- Candidiasis (candidiasis or thrush is a fungal infection): 3 people, 7.89%
- Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 3 people, 7.89%
- Cough: 3 people, 7.89%
- Depression: 3 people, 7.89%
- Hiccups (an involuntary spasm of the diaphragm and respiratory organs, with a sudden closure of the glottis and a sound like a cough): 3 people, 7.89%
* Approximation only. Some reports may have incomplete information.
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Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
Browse all drug interactions of Metformin and Anzemet:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Metformin:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Anzemet:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Metformin and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Anzemet and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- T.Audi Yanto, I.Huang, F.Nathania Kosasih, NP Hardjo Lugito, "Nightmare and Abnormal Dreams: Rare Side Effects of Metformin?", Case Reports in Endocrinology, 2018 Jan .
- Al-Hamdy RA, "Assessment of electrolytes and HbA1c in type 2 diabetic patients using metformin and evaluation of guidelines obedience regarding renal impairment", J.Thi-Qar Sci., 2015 Jan .
- Wiwanitkit S, Wiwanitkit V, "Metformin and sleep disorders", Indian journal of endocrinology and metabolism, 2012 Jan .
- T.Audi Yanto, I.Huang, F.Nathania Kosasih, NP Hardjo Lugito, "Nightmare and Abnormal Dreams: Rare Side Effects of Metformin?", Case Reports in Endocrinology, 2018 Jan .
- Al-Hamdy RA, "Assessment of electrolytes and HbA1c in type 2 diabetic patients using metformin and evaluation of guidelines obedience regarding renal impairment", J.Thi-Qar Sci., 2015 Jan .
- Wiwanitkit S, Wiwanitkit V, "Metformin and sleep disorders", Indian journal of endocrinology and metabolism, 2012 Jan .
How the study uses the data?
The study uses data from the FDA. It is based on metformin hydrochloride and dolasetron mesylate (the active ingredients of Metformin and Anzemet, respectively), and Metformin and Anzemet (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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