Focalin and Seroquel drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Focalin (dexmethylphenidate hydrochloride) and Seroquel (quetiapine fumarate). Common drug interactions include abdominal pain among females and convulsion among males.

The phase IV clinical study analyzes what interactions people have when they take Focalin and Seroquel. It is created by eHealthMe based on reports of 90 people who take the same drugs from the FDA, and is updated regularly.

What is Focalin?

Focalin has active ingredients of dexmethylphenidate hydrochloride. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 4,781 Focalin users. Check the latest studies of Focalin.

What is Seroquel?

Seroquel has active ingredients of quetiapine fumarate. It is often used in bipolar disorder. eHealthMe is studying from 120,285 Seroquel users. Check the latest studies of Seroquel.

On Jul, 15, 2026

90 people who take Focalin and Seroquel together, and have interactions are studied.

What are the common drug interactions of Focalin and Seroquel, by gender? *:

female:

Abdominal pain
Abdominal pain upper
Acne (skin problems that cause pimples)
Amenorrhoea (absence of a menstrual period in a woman of reproductive age)
Bunion (a painful swelling on the first joint of the big toe)
Cystitis (inflammation of the wall of the bladder)
Dermatitis atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder)
Ear pain
Gastroenteritis (inflammation of stomach and intestine)
Homicidal ideation (thoughts about human killing another human)

male:

Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Nausea (feeling of having an urge to vomit)
Obesity (having too much body fat)
Aggression
Irritability
Fatigue (feeling of tiredness)
Restlessness (not able to rest)
Agitation (state of anxiety or nervous excitement)
Hallucination, visual (seeing things that aren't there)

What are the common drug interactions of Focalin and Seroquel, by age (0-1 to 60+)? *:

0-1:

Neuroleptic malignant syndrome (a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic agents)

2-9:

Nausea (feeling of having an urge to vomit)
Blood glucose decreased
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Dysarthria (speech disorder)
Dystonia (abnormal muscle tone)
Fatigue (feeling of tiredness)
Inflammatory carcinoma of the breast
Metastases to muscle (cancer spreads to muscle)
Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness)
Muscle twitching

10-19:

Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Tardive dyskinesia (a disorder that involves involuntary movements)
Death
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Hyperglycaemia (high blood sugar)
Ketonuria (ketones in urine)
Type 1 diabetes mellitus
Sedation
Abdominal pain upper
Homicidal ideation (thoughts about human killing another human)

20-29:

Drug screen positive
Injection site bruising
Nausea (feeling of having an urge to vomit)
Wheezing (a high-pitched whistling sound made while you breath)
Abnormal behaviour
Anger
Thyroid disorder (thyroid diseases)
Injection site pain
Therapeutic response unexpected
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)

30-39:

Accident at work
Blood glucose increased
Diabetes mellitus inadequate control
Diabetic eye disease
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Diabetic retinopathy (damage to the retina caused by complications of diabetes)
Intervertebral disc protrusion (spinal disc protrusion)
Proteinuria (presence of protein in the urine)
Renal cyst (kidney cyst)
Suicide attempt

40-49:

Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Nausea (feeling of having an urge to vomit)
Pyrexia (fever)
Abdominal discomfort
Alopecia (absence of hair from areas of the body)
Asthenia (weakness)
Burning sensation
Chest discomfort
Constipation
Contusion (a type of hematoma of tissue in which capillaries)

50-59:

Heart rate increased
Palpitations (feelings or sensations that your heart is pounding or racing)
Renal disorder (kidney disease)
Ventricular tachycardia (rapid heartbeat that originates in one of the lower chambers (the ventricles) of the heart)

60+:

Arthritis (form of joint disorder that involves inflammation of one or more joints)
Asthma
Drug ineffective
Hypersensitivity
Initial insomnia (feeling of inadequate or poor-quality sleep)
Ligament rupture (tear in ligament)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Pruritus (severe itching of the skin)
Restlessness (not able to rest)
Therapeutic response unexpected

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 10 people, 11.11%
Sleep Disorder: 8 people, 8.89%
Depression: 8 people, 8.89%
Psoriasis (immune-mediated disease that affects the skin): 6 people, 6.67%
Oppositional Defiant Disorder (a childhood disorder described by the diagnostic and statistical manual of mental disorders): 5 people, 5.56%
Affective Disorder (mental disorder): 5 people, 5.56%

* Approximation only. Some reports may have incomplete information.

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