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Metformin and Thiola drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Metformin (metformin hydrochloride) and Thiola (tiopronin). Common drug interactions include drug ineffective among females and drug ineffective among males.

The phase IV clinical study analyzes what interactions people have when they take Metformin and Thiola. It is created by eHealthMe based on reports of 21 people who take the same drugs from the FDA, and is updated regularly.

What is Metformin?

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 465,354 Metformin users. Check the latest studies of Metformin.

What is Thiola?

Thiola has active ingredients of tiopronin. eHealthMe is studying from 1,842 Thiola users. Check the latest studies of Thiola.

On Jul, 10, 2026

21 people who take Metformin and Thiola together, and have interactions are studied.

Metformin and Thiola drug interactions.

What are the common drug interactions of Metformin and Thiola, by gender? *:

female:

  1. Drug ineffective
  2. Decreased appetite
  3. Discomfort
  4. Hypogeusia (reduced ability to taste things (to taste sweet, sour, bitter, or salty substances))
  5. Pain
  6. Blood pressure increased
  7. Nephrolithiasis (calculi in the kidneys)
  8. Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)

male:

  1. Drug ineffective
  2. Flank pain (a distressing sensation experienced around the lower back and the upper abdomen)
  3. Hyperglycaemia (high blood sugar)
  4. Localised infection (infection at the single location)
  5. Rash
  6. Blindness
  7. Eye infection fungal
  8. Flatulence (flatus expelled through the anus)
  9. Sepsis (a severe blood infection that can lead to organ failure and death)
  10. Skin irritation

What are the common drug interactions of Metformin and Thiola, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

  1. Drug ineffective
  2. Discomfort
  3. Pain

50-59:

  1. Drug ineffective
  2. Flank pain (a distressing sensation experienced around the lower back and the upper abdomen)
  3. Sepsis (a severe blood infection that can lead to organ failure and death)

60+:

  1. Drug ineffective
  2. Decreased appetite
  3. Hyperglycaemia (high blood sugar)
  4. Hypogeusia (reduced ability to taste things (to taste sweet, sour, bitter, or salty substances))
  5. Localised infection (infection at the single location)
  6. Rash
  7. Blindness
  8. Eye infection fungal
  9. Flatulence (flatus expelled through the anus)
  10. Skin irritation

What are the existing conditions these people have? *

  1. Cystinuria (formation of cystine stones in the kidneys, ureter, and bladder): 10 people, 47.62%
  2. Kidney Stones: 4 people, 19.05%
  3. Amino Acid Metabolism Disorder: 2 people, 9.52%

* Approximation only. Some reports may have incomplete information.

Do you take Metformin and Thiola?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Metformin and Thiola:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Metformin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Thiola:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Metformin and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Thiola and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on metformin hydrochloride and tiopronin (the active ingredients of Metformin and Thiola, respectively), and Metformin and Thiola (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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