Methadose and Dexamethasone drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Methadose (methadone hydrochloride) and Dexamethasone (dexamethasone). Common drug interactions include drug ineffective among females and confusional state among males.
The phase IV clinical study analyzes what interactions people have when they take Methadose and Dexamethasone. It is created by eHealthMe based on reports of 62 people who take the same drugs from the FDA, and is updated regularly.
What is Methadose?
Methadose has active ingredients of methadone hydrochloride. It is often used in pain. eHealthMe is studying from 5,101 Methadose users. Check the latest studies of Methadose.
What is Dexamethasone?
Dexamethasone has active ingredients of dexamethasone. It is often used in multiple myeloma. eHealthMe is studying from 161,927 Dexamethasone users. Check the latest studies of Dexamethasone.
62 people who take Methadose and Dexamethasone together, and have interactions are studied.

What are the common drug interactions of Methadose and Dexamethasone, by gender? *:
female:
- Drug ineffective
- Phyllodes tumour (breast tumour)
- Disease progression
- Musculoskeletal chest pain (pain in chest muscle or nerve or bones)
- Breast cancer recurrent
- Decreased interest
- Emotional distress
- Fatigue (feeling of tiredness)
- Hepatic steatosis (fatty liver disease)
- Hepatitis c
male:
- Confusional state
- Blood pressure diastolic increased
- Hemiparesis (weakness on one side of the body)
- Incoherent (talking in a confused and unclear way)
- Nerve injury
- Nervous system disorder (a general class of medical conditions affecting the nervous system)
- Rectal haemorrhage (bleeding from anus)
- Weight decreased
- Weight increased
- Bone marrow failure
What are the common drug interactions of Methadose and Dexamethasone, by age (0-1 to 60+)? *:
0-1:
- Asthenia (weakness)
- Progressive multifocal leukoencephalopathy (rapidly progressive neuromuscular disease caused by opportunistic infection of brain cells)
- Drug withdrawal syndrome neonatal (prenatal nas is caused by discontinuation of drugs taken by the pregnant mother)
- Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)
2-9:
n/a
10-19:
n/a
20-29:
n/a
30-39:
n/a
40-49:
- Blood pressure diastolic increased
- Blood pressure increased
- Body temperature decreased
- Bone marrow disorder
- Confusional state
- Dyspepsia (indigestion)
- Epistaxis (bleed from the nose)
- Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
- Haemorrhage (bleeding)
- Headache (pain in head)
50-59:
- Hepatic steatosis (fatty liver disease)
- Hepatitis c
- Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
- Hypokalaemia (low potassium)
- Injury
- Lung neoplasm (tumour of lung)
- Lymphadenopathy (disease or enlargement of lymph nodes)
- Malaise (a feeling of general discomfort or uneasiness)
- Mass
- Metastases to bone (cancer spreads to bone)
60+:
- Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
- Full blood count decreased
What are the existing conditions these people have? *
- Cancer Pain: 23 people, 37.10%
- Oligodendroglioma (a type of glioma that are believed to originate from the oligodendrocytes of the brain or from a glial precursor cell): 20 people, 32.26%
- Breast Cancer Metastatic: 13 people, 20.97%
- Resorption Bone Increased: 7 people, 11.29%
- Brain Cancer Metastatic: 6 people, 9.68%
* Approximation only. Some reports may have incomplete information.
Do you take Methadose and Dexamethasone?
- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously
Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
- Methadose (5,101 reports)
- Dexamethasone (161,927 reports)
Browse all drug interactions of Methadose and Dexamethasone:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Methadose:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Dexamethasone:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Methadose and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Dexamethasone and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- McFarlane SI, "Torsades de Pointes induced by Methadone and Clonazepam Use", , 2015 Jan .
- Ashkar AG, Goldberg T, Maraj I, Masters A, McFarlane SI, "Torsades De Pointes Induced by Methadone and Clonazepam Use", International Journal of Medical and Pharmaceutical Case Reports, 2015 Jan .
- McFarlane, S. I. , "Torsades de Pointes induced by Methadone and Clonazepam Use", , 2014 Jan .
- Bartlett R, Hartle AJ, "Routine use of dexamethasone for postoperative nausea and vomiting: the case against", Anaesthesia, 2013 Sep .
- McFarlane SI, "Torsades de Pointes induced by Methadone and Clonazepam Use", , 2015 Jan .
- Ashkar AG, Goldberg T, Maraj I, Masters A, McFarlane SI, "Torsades De Pointes Induced by Methadone and Clonazepam Use", International Journal of Medical and Pharmaceutical Case Reports, 2015 Jan .
- McFarlane, S. I. , "Torsades de Pointes induced by Methadone and Clonazepam Use", , 2014 Jan .
- Bartlett R, Hartle AJ, "Routine use of dexamethasone for postoperative nausea and vomiting: the case against", Anaesthesia, 2013 Sep .
How the study uses the data?
The study uses data from the FDA. It is based on methadone hydrochloride and dexamethasone (the active ingredients of Methadose and Dexamethasone, respectively), and Methadose and Dexamethasone (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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