Methotrexate sodium and Opdivo drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Methotrexate sodium (methotrexate sodium) and Opdivo (nivolumab). Common drug interactions include spondyloarthropathy among females and metastases to lung among males.

The phase IV clinical study analyzes what interactions people have when they take Methotrexate sodium and Opdivo. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Methotrexate sodium?

Methotrexate sodium has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 97,679 Methotrexate sodium users. Check the latest studies of Methotrexate sodium.

What is Opdivo?

Opdivo has active ingredients of nivolumab. eHealthMe is studying from 56,331 Opdivo users. Check the latest studies of Opdivo.

On Jul, 16, 2026

11 people who take Methotrexate sodium and Opdivo together, and have interactions are studied.

Methotrexate sodium and Opdivo drug interactions.

What are the common drug interactions of Methotrexate Sodium and Opdivo, by gender? *:

female:

Spondyloarthropathy (any joint disease of the vertebral column)
Uveitis (inflammation of the uvea)
Death
Mixed liver injury

male:

Metastases to lung (cancer spreads to lung)
Pneumonitis (inflammation of the walls of the alveoli in the lungs)
Arthralgia (joint pain)
Dyspnoea (difficult or laboured respiration)
Hypopituitarism (diminished hormone secretion by the pituitary gland, causing dwarfism in children and premature aging in adults)
Lung disorder (lung disease)
Polyarthritis (arthritis which involves 5 or more joints simultaneously)
Weight decreased

What are the common drug interactions of Methotrexate Sodium and Opdivo, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Spondyloarthropathy (any joint disease of the vertebral column)
Uveitis (inflammation of the uvea)

60+:

Death
Metastases to lung (cancer spreads to lung)
Pneumonitis (inflammation of the walls of the alveoli in the lungs)
Mixed liver injury
Arthralgia (joint pain)
Dyspnoea (difficult or laboured respiration)
Hypopituitarism (diminished hormone secretion by the pituitary gland, causing dwarfism in children and premature aging in adults)
Lung disorder (lung disease)
Polyarthritis (arthritis which involves 5 or more joints simultaneously)
Weight decreased

What are the existing conditions these people have? *

Metastatic Renal Cell Carcinoma (spreadable kidney cell tumour): 3 people, 27.27%
Metastases To Spine (cancer spreads to spine): 3 people, 27.27%
Metastases To Lung (cancer spreads to lung): 3 people, 27.27%
Renal Cell Carcinoma (a kidney cancer): 2 people, 18.18%
Metastatic Malignant Melanoma (spreadable cancer tumour of melanine): 1 person, 9.09%
Malignant Melanoma (skin cancer rises from melancytes): 1 person, 9.09%
Lung Cancer - Non-Small Cell (lung cancer): 1 person, 9.09%
High Blood Pressure: 1 person, 9.09%
Dyslipidaemia (abnormal amount of lipids): 1 person, 9.09%
Carotid Artery Stenosis (narrowing of carotid artery): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

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