Methotrexate and Coreg cr drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Methotrexate (methotrexate sodium) and Coreg cr (carvedilol phosphate). Common drug interactions include atrioventricular block among females and fall among males.

The phase IV clinical study analyzes what interactions people have when they take Methotrexate and Coreg cr. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 604,313 Methotrexate users. Check the latest studies of Methotrexate.

What is Coreg cr?

Coreg cr has active ingredients of carvedilol phosphate. It is often used in high blood pressure. eHealthMe is studying from 1,628 Coreg cr users. Check the latest studies of Coreg cr.

On Aug, 07, 2026

18 people who take Methotrexate and Coreg cr together, and have interactions are studied.

Methotrexate and Coreg cr drug interactions.

What are the common drug interactions of Methotrexate and Coreg Cr, by gender? *:

female:

Atrioventricular block (heart block)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Injection site pain
Joint range of motion decreased (disease of joint movement)
Localised infection (infection at the single location)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Tendonitis (a condition that causes pain and swelling of tendons)
Blood pressure fluctuation
Cardiac pacemaker replacement
Cardiovascular disorder (heart diseases)

male:

Fall
Pruritus (severe itching of the skin)
Abscess (pus)
Cellulitis staphylococcal (a type of bacteria originated skin soft tissue infection)
Hip fracture
Rash erythematous (redness of the skin)
Ulcer haemorrhage (bleeding ulcer)
Vertigo

What are the common drug interactions of Methotrexate and Coreg Cr, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Vertigo

30-39:

n/a

40-49:

Blood glucose increased
Chest discomfort
Chills (felling of cold)
Dizziness
Drug hypersensitivity
Erythema (redness of the skin)
Feeling hot
Gallbladder pain
Headache (pain in head)
Heart rate increased

50-59:

Cellulitis (infection under the skin)
Phlebitis (inflammation of the walls of a vein)
Thrombosis (formation of a blood clot inside a blood vessel)

60+:

Arthralgia (joint pain)
Joint range of motion decreased (disease of joint movement)
Hip fracture
Hyperhidrosis (abnormally increased sweating)
Injection site pain
Local swelling (swelling at the site of some application of substance or injury)
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Oral mucosal blistering (mouth ulcer)
Rash erythematous (redness of the skin)
Visual impairment

What are the existing conditions these people have? *

Cardiac Disorder: 3 people, 16.67%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 11.11%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 11.11%
Cardiac Failure Congestive: 2 people, 11.11%
High Blood Cholesterol: 2 people, 11.11%
Gastric Disorder (disease of stomach): 2 people, 11.11%
Fibromyalgia (a long-term condition which causes pain all over the body): 1 person, 5.56%
Asthma: 1 person, 5.56%
B-Cell Lymphoma Stage Iv (blood cancer affecting b cells stage iv): 1 person, 5.56%
Cardiomyopathy (weakening of the heart muscle): 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

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