Methotrexate and Duobrii drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Methotrexate (methotrexate sodium) and Duobrii (halobetasol propionate; tazarotene). Common drug interactions include headache among females and psoriasis among males.

The phase IV clinical study analyzes what interactions people have when they take Methotrexate and Duobrii. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 604,312 Methotrexate users. Check the latest studies of Methotrexate.

What is Duobrii?

Duobrii has active ingredients of halobetasol propionate; tazarotene. eHealthMe is studying from 212 Duobrii users. Check the latest studies of Duobrii.

On Jul, 12, 2026

20 people who take Methotrexate and Duobrii together, and have interactions are studied.

Methotrexate and Duobrii drug interactions.

What are the common drug interactions of Methotrexate and Duobrii, by gender? *:

female:

Headache (pain in head)
Abdominal pain upper
Aggression
Anaphylactic shock (severe and rapid and sometimes fatal hypersensitivity reaction to a substance)
Asthenia (weakness)
Breast swelling
Dehydration (dryness resulting from the removal of water)
Diarrhoea
Disturbance in attention
Drug hypersensitivity

male:

Psoriasis (immune-mediated disease that affects the skin)
Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
Skin cancer
Skin fissures (a crack in the skin)
Skin lesion
Vision blurred
Cellulitis (infection under the skin)
Osteomyelitis (infection of bone)
Seborrhoea (a disease of the sebaceous glands characterized by excessive secretion of sebum)
Squamous cell carcinoma (a cancer of a kind of epithelial cell)

What are the common drug interactions of Methotrexate and Duobrii, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings)

50-59:

Abdominal pain upper
Aggression
Anaphylactic shock (severe and rapid and sometimes fatal hypersensitivity reaction to a substance)
Asthenia (weakness)
Breast swelling
Dehydration (dryness resulting from the removal of water)
Diarrhoea
Disturbance in attention
Drug hypersensitivity
Drug ineffective

60+:

Squamous cell carcinoma (a cancer of a kind of epithelial cell)
Psoriasis (immune-mediated disease that affects the skin)
Keratoacanthoma (a common low-grade (unlikely to metastasize or invade) skin tumour that is believed to originate from the neck of the hair follicle)
Lichenoid keratosis (a skin disorder described by rapid growing, reddish to brown, benign (noncancerous) lesion on the skin)
Osteomyelitis (infection of bone)
Seborrhoea (a disease of the sebaceous glands characterized by excessive secretion of sebum)
Surgery
Dyspepsia (indigestion)
Headache (pain in head)
Knee arthroplasty

What are the existing conditions these people have? *

Psoriasis (immune-mediated disease that affects the skin): 7 people, 35.00%
Diabetes: 4 people, 20.00%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 3 people, 15.00%
High Blood Pressure: 3 people, 15.00%
Skin Cancer: 2 people, 10.00%
Post Herpetic Neuralgia (neuralgia caused by the varicella zoster virus): 2 people, 10.00%
Gastrointestinal Disorder (functional problems of gastrointestinal tract): 2 people, 10.00%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 2 people, 10.00%
Dermatitis Atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder): 1 person, 5.00%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

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