Methotrexate and Envarsus xr drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Methotrexate (methotrexate sodium) and Envarsus xr (tacrolimus). Common drug interactions include hemiparesis among females and graft versus host disease among males.

The phase IV clinical study analyzes what interactions people have when they take Methotrexate and Envarsus xr. It is created by eHealthMe based on reports of 51 people who take the same drugs from the FDA, and is updated regularly.

What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 604,313 Methotrexate users. Check the latest studies of Methotrexate.

What is Envarsus xr?

Envarsus xr has active ingredients of tacrolimus. eHealthMe is studying from 3,819 Envarsus xr users. Check the latest studies of Envarsus xr.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 14, 2026

51 people who take Methotrexate and Envarsus xr together, and have interactions are studied.

Methotrexate and Envarsus xr drug interactions.

What are the common drug interactions of Methotrexate and Envarsus Xr, by gender? *:

female:

Hemiparesis (weakness on one side of the body)
Jc virus infection
Leukopenia (less number of white blood cells in blood)
Lung infiltration (a substance that normally includes fluid, inflammatory exudates or cells that fill a region of lung)
Myopathy (a muscular disease in which the muscle fibres do not function)
Neutropenia (an abnormally low number of neutrophils)
Pigmentation disorder (disturbances of human skin colour)
Poisoning deliberate
Progressive multifocal leukoencephalopathy (rapidly progressive neuromuscular disease caused by opportunistic infection of brain cells)
Pulmonary embolism (blockage of the main artery of the lung)

male:

Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Drug ineffective
Graft versus host disease in liver (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the liver)
Mucosal inflammation (infection of mucous membrane)
Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
Bone pain
Brain herniation (brain herniation is a potentially deadly side effect of very high intracranial pressure that occurs when a part of the brain is squeezed across structures within the skull)
Circulatory collapse
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)

What are the common drug interactions of Methotrexate and Envarsus Xr, by age (0-1 to 60+)? *:

0-1:

Neutropenia (an abnormally low number of neutrophils)
Rhinovirus infection

2-9:

Drug ineffective
Intussusception
Thrombocytopenia (decrease of platelets in blood)
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Enterobacter infection (infection caused by bacteria of the family enterobacteriaceae)
Epstein-barr viraemia
Graft versus host disease in skin (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the skin)
Otitis media bacterial (inflammation of the middle ear by bacteria)
Rash maculo-papular (red area on the skin that is covered with small confluent bumps)
Sepsis (a severe blood infection that can lead to organ failure and death)

10-19:

Pruritus (severe itching of the skin)
Therapeutic response decreased (less preventive response)
Ulcer
Ear infection
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Pneumonia
Acute graft versus host disease (acute complication following an allogeneic tissue/blood transplant)
Sinusitis bacterial (bacterial infection of sinus)
Pulmonary mycosis (lung infection caused by yeast-like fungi)
Epstein-barr virus associated lymphoma (epstein-barr virus associated tumour)

20-29:

Obliterative bronchiolitis (bronchiolar inflammation)
Pneumonia
Chronic graft versus host disease (immune cells attack the host's body cells after transplant)
Chronic graft versus host disease in skin (damage by immune cells to skin after grafting)
Dry eye (lack of adequate tears)
Diarrhoea
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Hypertension (high blood pressure)
Hypokalaemia (low potassium)

30-39:

Acute hepatic failure
Ankylosing spondylitis (type of arthritis affecting the spine)
Anorexia nervosa (psychological disorder-eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Asthma
Dissociative disorder
Drug hypersensitivity
Drug intolerance (drug sensitivity)
Infectious mononucleosis (infection usually caused by the epstein-barr virus)
Nausea (feeling of having an urge to vomit)
Ill-defined disorder

40-49:

Lung infiltration (a substance that normally includes fluid, inflammatory exudates or cells that fill a region of lung)
Pneumonia
Pulmonary embolism (blockage of the main artery of the lung)

50-59:

Aphasia (damage to the parts of the brain that control language)
Bone pain
Drug ineffective
Duodenitis (inflammation of the duodenum)
Hemiparesis (weakness on one side of the body)
Jc virus infection
Myalgia (muscle pain)
Myopathy (a muscular disease in which the muscle fibres do not function)
Oesophageal achalasia (difficulty swallowing, food sticking in the oesophagus)
Pancreatitis (inflammation of pancreas)

60+:

Vomiting
Apraxia (disorder that affects a person's ability to organize the movements of the muscles used in speech)
Encephalopathy (functioning of the brain is affected by some agent or condition)
Epstein-barr viraemia
Fatigue (feeling of tiredness)
Hepatic failure (liver failure)
Infectious thyroiditis (inflammation of the thyroid gland due to infection)
Joint effusion (presence of extra fluid in joint covering)
Myopathy (a muscular disease in which the muscle fibres do not function)
Osteomyelitis (infection of bone)

What are the existing conditions these people have? *

Graft Versus Host Disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body): 15 people, 29.41%
Acute Graft Versus Host Disease (acute complication following an allogeneic tissue/blood transplant): 3 people, 5.88%

* Approximation only. Some reports may have incomplete information.

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