Methotrexate and Minipress drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Methotrexate (methotrexate sodium) and Minipress (prazosin hydrochloride). Common drug interactions include cardiac failure congestive among females and priapism among males.

The phase IV clinical study analyzes what interactions people have when they take Methotrexate and Minipress. It is created by eHealthMe based on reports of 32 people who take the same drugs from the FDA, and is updated regularly.

What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 604,312 Methotrexate users. Check the latest studies of Methotrexate.

What is Minipress?

Minipress has active ingredients of prazosin hydrochloride. It is often used in post-traumatic stress disorder. eHealthMe is studying from 2,213 Minipress users. Check the latest studies of Minipress.

On Jul, 11, 2026

32 people who take Methotrexate and Minipress together, and have interactions are studied.

Methotrexate and Minipress drug interactions.

What are the common drug interactions of Methotrexate and Minipress, by gender? *:

female:

Cardiac failure congestive
Cardiomegaly (increased size of heart than normal)
Contusion (a type of hematoma of tissue in which capillaries)
Cystitis (inflammation of the wall of the bladder)
Decreased appetite
Device dislocation
Drug eruption (adverse drug reaction of the skin)
Drug ineffective
Dyspepsia (indigestion)
Functional gastrointestinal disorder (functional problem in separate organs of gastrointestinal system)

male:

Priapism (prolonged and painful erection that can last from several hours up to a few days)
Pain
Injection site pain
Paraesthesia oral (sensation of tingling, tickling, prickling, pricking, or burning of a person's oral with no apparent long-term physical effect)
Penile pain
Penile swelling
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Presyncope
Psoriasis (immune-mediated disease that affects the skin)
Rib fracture

What are the common drug interactions of Methotrexate and Minipress, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Fall
Fluid retention (an abnormal accumulation of fluid in the blood)
Haemorrhage (bleeding)
Headache (pain in head)
Infusion related reaction
Intestinal obstruction
Migraine (headache)
Myelitis transverse (a neurological condition consisting of an inflammatory process of the spinal cord)
Oropharyngeal pain
Post procedural infection

20-29:

n/a

30-39:

Priapism (prolonged and painful erection that can last from several hours up to a few days)
C-reactive protein increased
Pain
Penile pain
Penile swelling
Swelling
Balanitis (inflammation of the glands penis)
Haemorrhage (bleeding)
Localised skin reaction (skin reaction at single location)

40-49:

Diplopia (double vision)
Drug ineffective
Dyspepsia (indigestion)
Eye disorder
Immune system disorder
Metastatic lymphoma (spreadable cancer tumour of lymph node)
Muscular weakness (muscle weakness)
Neurotoxicity (when the exposure to natural or artificial toxic substances, which are called neurotoxins, alters the normal activity of the nervous system)
Pneumonia
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)

50-59:

Anxiety
Dizziness
Head discomfort
Headache (pain in head)
Hypoaesthesia (reduced sense of touch or sensation)
Injection site pain
Paraesthesia oral (sensation of tingling, tickling, prickling, pricking, or burning of a person's oral with no apparent long-term physical effect)
Presyncope
Psoriasis (immune-mediated disease that affects the skin)
Swollen tongue (swelling of tongue)

60+:

Weight decreased
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Nausea (feeling of having an urge to vomit)
Rib fracture
Abdominal distension
Abdominal pain
Anaemia (lack of blood)
Ascites (accumulation of fluid in the abdominal cavity)
Asthma
Atelectasis (partial or complete collapse of the lung)

What are the existing conditions these people have? *

Psoriasis (immune-mediated disease that affects the skin): 6 people, 18.75%
Hypogammaglobulinaemia (an abnormally low concentration of gamma globulin in the blood and increased risk of infection): 3 people, 9.38%
High Blood Pressure: 3 people, 9.38%
Rashes (redness): 2 people, 6.25%
Immunodeficiency Common Variable: 2 people, 6.25%
Ill-Defined Disorder: 2 people, 6.25%
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it): 2 people, 6.25%

* Approximation only. Some reports may have incomplete information.

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