Methotrexate and Optimark drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Methotrexate (methotrexate sodium) and Optimark (gadoversetamide). Common drug interactions include deformity among females and mobility decreased among males.

The phase IV clinical study analyzes what interactions people have when they take Methotrexate and Optimark. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 604,313 Methotrexate users. Check the latest studies of Methotrexate.

What is Optimark?

Optimark has active ingredients of gadoversetamide. eHealthMe is studying from 3,055 Optimark users. Check the latest studies of Optimark.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 15, 2026

18 people who take Methotrexate and Optimark together, and have interactions are studied.

Methotrexate and Optimark drug interactions.

What are the common drug interactions of Methotrexate and Optimark, by gender? *:

female:

Deformity (disfigurement)
Erythema (redness of the skin)
Fibrosis (formation of excess fibrous connective tissue in an organ or tissue)
General physical health deterioration (weak health status)
Joint stiffness
Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Oedema peripheral (superficial swelling)
Pain
Pain of skin
Scar

male:

Mobility decreased (ability to move is reduced)
Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Xerosis (abnormal dryness of the skin or mucus membranes)
Cardiac arrest
Endocardial fibrosis (cardiac fibrosis refers to an abnormal thickening of the heart valves)
Joint contracture (a permanent shortening of a muscle or joint)
Skin fibrosis (fibrous tissue formation on skin)
Discomfort
Pain
Muscle contracture (a permanent shortening of a muscle)

What are the common drug interactions of Methotrexate and Optimark, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Fibrosis (formation of excess fibrous connective tissue in an organ or tissue)
Metaplasia (change in the type of adult cells in a tissue to a form abnormal for that tissue)
Mobility decreased (ability to move is reduced)
Myocardial fibrosis (a condition in which the heart's muscle cells are impaired)
Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Pain in extremity
Pulmonary fibrosis (formation or development of excess fibrous connective tissue (fibrosis) in the lungs)
Skin induration (an abnormally hard spot or area on the skin)
Skin tightness
Subcutaneous nodule

20-29:

n/a

30-39:

n/a

40-49:

Deformity (disfigurement)
Erythema (redness of the skin)
Fibrosis (formation of excess fibrous connective tissue in an organ or tissue)
General physical health deterioration (weak health status)
Joint stiffness
Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Oedema (fluid collection in tissue)
Oedema peripheral (superficial swelling)
Pain
Pain of skin

50-59:

Erythema (redness of the skin)
General physical health deterioration (weak health status)
Skin exfoliation (removal of the oldest dead skin cells)
Skin fibrosis (fibrous tissue formation on skin)
Skin induration (an abnormally hard spot or area on the skin)
Mobility decreased (ability to move is reduced)
Pain in extremity
Skin tightness
Arthralgia (joint pain)
Bone pain

60+:

n/a

What are the existing conditions these people have? *

Synovitis (inflammation of the synovial membrane): 5 people, 27.78%
Nuclear Magnetic Resonance Imaging Brain: 5 people, 27.78%
Joint Deposit (deposit in joint): 5 people, 27.78%
Renal Osteodystrophy (a bone disease occurs when the kidneys fail to maintain the proper levels of calcium and phosphorus in the blood): 3 people, 16.67%
Joint Pain: 3 people, 16.67%
Hypercalcaemia (elevated calcium (ca+) level in the blood): 3 people, 16.67%
Headache (pain in head): 3 people, 16.67%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 3 people, 16.67%
Catheter Related Complication: 2 people, 11.11%
Medical Device Complication: 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

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