Methotrexate and Panadol drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Methotrexate (methotrexate sodium) and Panadol (acetaminophen). Common drug interactions include upper limb fracture among females and arthralgia among males.

The phase IV clinical study analyzes what interactions people have when they take Methotrexate and Panadol. It is created by eHealthMe based on reports of 30 people who take the same drugs from the FDA, and is updated regularly.

What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 604,313 Methotrexate users. Check the latest studies of Methotrexate.

What is Panadol?

Panadol has active ingredients of acetaminophen. eHealthMe is studying from 607 Panadol users. Check the latest studies of Panadol.

On Aug, 09, 2026

30 people who take Methotrexate and Panadol together, and have interactions are studied.

Methotrexate and Panadol drug interactions.

What are the common drug interactions of Methotrexate and Panadol, by gender? *:

female:

Upper limb fracture
Uterine disorder
Arthralgia (joint pain)
Fall
Pain
Dizziness
Paraesthesia oral (sensation of tingling, tickling, prickling, pricking, or burning of a person's oral with no apparent long-term physical effect)
Swollen tongue (swelling of tongue)
Throat tightness
Drug intolerance (drug sensitivity)

male:

Arthralgia (joint pain)
Lower respiratory tract infection
Hypersensitivity
Pain
Papule
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Periodontal disease (disease that attacks the gum and bone and around the teeth)
Pruritus (severe itching of the skin)
Renal impairment (severely reduced kidney function)
Skin burning sensation

What are the common drug interactions of Methotrexate and Panadol, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Skin burning sensation
Skin exfoliation (removal of the oldest dead skin cells)
Arthralgia (joint pain)
Chest pain
Dehydration (dryness resulting from the removal of water)
Dizziness
Fatigue (feeling of tiredness)
Giardiasis (intestinal infection caused by the parasite giardia lamblia)
Headache (pain in head)
Nausea (feeling of having an urge to vomit)

50-59:

Arthralgia (joint pain)
Blood pressure increased
Dizziness
Folliculitis (infection of hair root)
Foot deformity (functional disability of foot)
Infusion site pain
Pain
Staphylococcal abscess (pus formation due to staphylococcal bacteria)
Abdominal discomfort
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)

60+:

Fall
Joint injury
Urinary tract infection
Urosepsis (secondary infection that occurs when a urinary tract infection spreads to the bloodstream)
Acute myocardial infarction (acute heart attack)
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
Alanine aminotransferase increased
Amyotrophic lateral sclerosis (nervous system disease that attacks nerve cells called neurons in your brain and spinal cord)
Anaemia (lack of blood)
Anxiety

What are the existing conditions these people have? *

Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve): 3 people, 10.00%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 3 people, 10.00%
Back Pain: 3 people, 10.00%
Dry Eyes (lack of adequate tears): 2 people, 6.67%

* Approximation only. Some reports may have incomplete information.

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