Methotrexate and Prednicarbate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Methotrexate (methotrexate sodium) and Prednicarbate (prednicarbate). Common drug interactions include haemangioma among females and coronary artery occlusion among males.

The phase IV clinical study analyzes what interactions people have when they take Methotrexate and Prednicarbate. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 604,312 Methotrexate users. Check the latest studies of Methotrexate.

What is Prednicarbate?

Prednicarbate has active ingredients of prednicarbate. eHealthMe is studying from 298 Prednicarbate users. Check the latest studies of Prednicarbate.



On Jul, 07, 2026

12 people who take Methotrexate and Prednicarbate together, and have interactions are studied.

Methotrexate and Prednicarbate drug interactions.

What are the common drug interactions of Methotrexate and Prednicarbate, by gender? *:

female:

  1. Haemangioma (noncancerous, abnormally dense collections of dilated small blood vessels that may occur in the skin or internal organs)
  2. Haematuria (presence of blood in urine)
  3. Hepatic enzyme increased
  4. Infection
  5. Infusion related reaction
  6. Pityriasis rubra pilaris (reddish-orange colour scaling patches with well defined borders)
  7. Respiratory failure (inadequate gas exchange by the respiratory system)
  8. Spleen disorder (disease of spleen)
  9. Intraductal papillary mucinous neoplasm (tumour (neoplasm) that grows within the pancreatic ducts)
  10. Fibromyalgia (a long-term condition which causes pain all over the body)

male:

  1. Coronary artery occlusion (complete obstruction of blood flow in a coronary artery)
  2. Fatigue (feeling of tiredness)
  3. Migraine (headache)
  4. Nausea (feeling of having an urge to vomit)
  5. Tuberculin test positive

What are the common drug interactions of Methotrexate and Prednicarbate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

  1. Fibromyalgia (a long-term condition which causes pain all over the body)
  2. Cough
  3. Haemangioma (noncancerous, abnormally dense collections of dilated small blood vessels that may occur in the skin or internal organs)
  4. Haematuria (presence of blood in urine)
  5. Infection
  6. Infusion related reaction
  7. Spleen disorder (disease of spleen)

40-49:

  1. Tuberculin test positive
  2. Coronary artery occlusion (complete obstruction of blood flow in a coronary artery)
  3. Fatigue (feeling of tiredness)
  4. Migraine (headache)
  5. Nausea (feeling of having an urge to vomit)

50-59:

  1. Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
  2. Respiratory failure (inadequate gas exchange by the respiratory system)

60+:

  1. Intraductal papillary mucinous neoplasm (tumour (neoplasm) that grows within the pancreatic ducts)
  2. Drug ineffective
  3. Hepatic enzyme increased
  4. Pityriasis rubra pilaris (reddish-orange colour scaling patches with well defined borders)

What are the existing conditions these people have? *

  1. Dermatitis Atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder): 6 people, 50.00%
  2. Neurodermatitis (a skin disorder characterized by long lasting itching and scratching): 6 people, 50.00%
  3. Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 3 people, 25.00%
  4. Depression: 3 people, 25.00%
  5. Psoriasis (immune-mediated disease that affects the skin): 3 people, 25.00%
  6. High Blood Pressure: 3 people, 25.00%
  7. Weight Loss: 2 people, 16.67%
  8. Hypovitaminosis (any of several diseases caused by deficiency of one or more vitamins): 2 people, 16.67%
  9. Dyslipidaemia (abnormal amount of lipids): 2 people, 16.67%
  10. Amaurosis Fugax (painless transient monocular visual loss): 2 people, 16.67%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Methotrexate and Prednicarbate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Methotrexate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Prednicarbate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Methotrexate and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Prednicarbate and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on methotrexate sodium and prednicarbate (the active ingredients of Methotrexate and Prednicarbate, respectively), and Methotrexate and Prednicarbate (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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