Methotrexate and Roxicet drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Methotrexate (methotrexate sodium) and Roxicet (acetaminophen; oxycodone hydrochloride). Common drug interactions include depression among females and neuropathy peripheral among males.

The phase IV clinical study analyzes what interactions people have when they take Methotrexate and Roxicet. It is created by eHealthMe based on reports of 48 people who take the same drugs from the FDA, and is updated regularly.

What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 604,312 Methotrexate users. Check the latest studies of Methotrexate.

What is Roxicet?

Roxicet has active ingredients of acetaminophen; oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 2,254 Roxicet users. Check the latest studies of Roxicet.

On Jul, 12, 2026

48 people who take Methotrexate and Roxicet together, and have interactions are studied.

Methotrexate and Roxicet drug interactions.

What are the common drug interactions of Methotrexate and Roxicet, by gender? *:

female:

Depression
Dyspepsia (indigestion)
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Swelling face
Arthralgia (joint pain)
Back pain
Herpes zoster
Neoplasm progression (growth of tumour)
Osteolysis (dissolution of bone)
Spinal osteoarthritis (joint cartilage loss in spine)

male:

Neuropathy peripheral (surface nerve damage)
Anxiety
Cardiac failure congestive
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Cardiomegaly (increased size of heart than normal)
Chest pain
Diabetes mellitus inadequate control
Electrolyte imbalance
Gait disturbance
Haemorrhage (bleeding)

What are the common drug interactions of Methotrexate and Roxicet, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Oedema peripheral (superficial swelling)
Pain in extremity

30-39:

n/a

40-49:

Anxiety
Hypoaesthesia (reduced sense of touch or sensation)
Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node)
Abdominal pain
Neuropathy peripheral (surface nerve damage)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Dysphagia (a condition in which swallowing is difficult or painful)
Dyspnoea (difficult or laboured respiration)
Weight decreased
Abscess (pus)

50-59:

Renal failure (kidney dysfunction)
Stress
Fatigue (feeling of tiredness)
Nervous system disorder (a general class of medical conditions affecting the nervous system)
Renal injury (kidney injury)
Sensation of heaviness
Therapeutic response decreased (less preventive response)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Anxiety
Depression

60+:

Gait disturbance
Neuropathy peripheral (surface nerve damage)
Injection site erythema (redness at injection site)
Injection site haemorrhage (bleeding from injection site)
Injection site irritation
Injection site scab
Abdominal discomfort
Adverse drug reaction
Anaemia (lack of blood)
Angioedema (rapid swelling of the dermis)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 14 people, 29.17%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 11 people, 22.92%
Neoplasm Malignant (cancer tumour): 9 people, 18.75%
Osteoporosis (bones weak and more likely to break): 8 people, 16.67%
Breast Cancer Metastatic: 8 people, 16.67%
High Blood Pressure: 5 people, 10.42%
High Blood Cholesterol: 4 people, 8.33%
Stress And Anxiety: 3 people, 6.25%
Nausea And Vomiting: 3 people, 6.25%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 6.25%

* Approximation only. Some reports may have incomplete information.

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