Methylphenidate hydrochloride and Fentanyl drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Methylphenidate hydrochloride (methylphenidate hydrochloride) and Fentanyl (fentanyl citrate). Common drug interactions include constipation among females and unresponsive to stimuli among males.

The phase IV clinical study analyzes what interactions people have when they take Methylphenidate hydrochloride and Fentanyl. It is created by eHealthMe based on reports of 61 people who take the same drugs from the FDA, and is updated regularly.

What is Methylphenidate hydrochloride?

Methylphenidate hydrochloride has active ingredients of methylphenidate hydrochloride. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 6,822 Methylphenidate hydrochloride users. Check the latest studies of Methylphenidate hydrochloride.

What is Fentanyl?

Fentanyl has active ingredients of fentanyl citrate. It is often used in pain. eHealthMe is studying from 73,301 Fentanyl users. Check the latest studies of Fentanyl.

On Jul, 07, 2026

61 people who take Methylphenidate hydrochloride and Fentanyl together, and have interactions are studied.

Methylphenidate hydrochloride and Fentanyl drug interactions.

What are the common drug interactions of Methylphenidate Hydrochloride and Fentanyl, by gender? *:

female:

Constipation
Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Drug abuse
Epistaxis (bleed from the nose)
Face oedema (swelling of face)
Headache (pain in head)
Hypersensitivity
Mood altered (changes in mood)
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)

male:

Unresponsive to stimuli
Agitation (state of anxiety or nervous excitement)
Nausea (feeling of having an urge to vomit)
Tremor (trembling or shaking movements in one or more parts of your body)
Hypertension (high blood pressure)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Akathisia (a movement disorder characterized by a feeling of inner restlessness)
Binocular eye movement disorder
Hyperkinesia (higher than normal levels of potassium in the circulating blood; associated with kidney failure or sometimes with the use of diuretic drugs)
Hyperthermia (body temperature greatly above normal)

What are the common drug interactions of Methylphenidate Hydrochloride and Fentanyl, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Bradycardia (abnormally slow heart action)
Brain oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain)
Hypertension (high blood pressure)
Hypotension (abnormally low blood pressure)
Hypothermia (body temperature drops below the required temperature for normal metabolism and body functions)
Hypoxia (low oxygen in tissues)
Spinal cord compression
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Water intoxication (water poisoning)

10-19:

Cardiac arrest
Death
Respiratory arrest (cessation of normal respiration due to failure of the lungs to function effectively)

20-29:

Pulmonary oedema (fluid accumulation in the lungs)
Drug abuse
Brain oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain)

30-39:

Overdose
Drug level increased
Unresponsive to stimuli
Application site discharge
Application site excoriation (application site superficial loss of substance, as that produced on the skin by scratching)
Application site vesicles (small bubble within a cell at application site)
Brain oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain)
Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens)
Ecchymosis (a discoloration of the skin resulting from bleeding underneath)
Hypertonia (abnormal increase in muscle tension and a reduced ability of a muscle to stretch)

40-49:

Drug ineffective
Agitation (state of anxiety or nervous excitement)
Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time)
Akathisia (a movement disorder characterized by a feeling of inner restlessness)
Binocular eye movement disorder
Hyperkinesia (higher than normal levels of potassium in the circulating blood; associated with kidney failure or sometimes with the use of diuretic drugs)
Hypertension (high blood pressure)
Hyperthermia (body temperature greatly above normal)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)

50-59:

Abdominal discomfort
Aphthous stomatitis (mouth ulcer)
Cardiac arrest
Constipation
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diarrhoea
Drug abuse
Epistaxis (bleed from the nose)
Face oedema (swelling of face)
Hypersensitivity

60+:

Colitis ulcerative (inflammation of colon with ulcer)
Death
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Drug hypersensitivity
Erythema (redness of the skin)
Hypertension (high blood pressure)
Hypotension (abnormally low blood pressure)
Large intestinal obstruction
Lung cancer metastatic (lung cancer spreads to other parts)
Malignant neoplasm progression (cancer tumour came back)

What are the existing conditions these people have? *

Depression: 8 people, 13.11%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 8.20%
Multiple Myeloma (cancer of the plasma cells): 4 people, 6.56%
Drowsiness: 4 people, 6.56%

* Approximation only. Some reports may have incomplete information.

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