1. Home
  2. Analysis
  3. Methylphenidate-hydrochloride
  4. Mirapex

Methylphenidate hydrochloride and Mirapex drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Methylphenidate hydrochloride (methylphenidate hydrochloride) and Mirapex (pramipexole dihydrochloride). Common drug interactions include back pain among females and abdominal neoplasm among males.

The phase IV clinical study analyzes what interactions people have when they take Methylphenidate hydrochloride and Mirapex. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Methylphenidate hydrochloride?

Methylphenidate hydrochloride has active ingredients of methylphenidate hydrochloride. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 6,822 Methylphenidate hydrochloride users. Check the latest studies of Methylphenidate hydrochloride.

What is Mirapex?

Mirapex has active ingredients of pramipexole dihydrochloride. It is often used in restless leg syndrome. eHealthMe is studying from 20,622 Mirapex users. Check the latest studies of Mirapex.

On Jul, 12, 2026

14 people who take Methylphenidate hydrochloride and Mirapex together, and have interactions are studied.

Methylphenidate hydrochloride and Mirapex drug interactions.

What are the common drug interactions of Methylphenidate Hydrochloride and Mirapex, by gender? *:

female:

  1. Back pain
  2. Arthralgia (joint pain)
  3. Blood urine present
  4. Bone pain
  5. Chronic sinusitis (long lasting inflammation of the paranasal sinuses)
  6. Dehydration (dryness resulting from the removal of water)
  7. Facial pain
  8. Fungal infection
  9. Gastrointestinal viral infection (virus infection of gastrointestinal tract)
  10. Headache (pain in head)

male:

  1. Abdominal neoplasm (cancer of the stomach)
  2. Anxiety
  3. Panic attack
  4. Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
  5. Dehydration (dryness resulting from the removal of water)
  6. Dental caries
  7. Drug effect decreased
  8. Exposure to toxic agent
  9. Hypotension (abnormally low blood pressure)
  10. Insomnia (sleeplessness)

What are the common drug interactions of Methylphenidate Hydrochloride and Mirapex, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

  1. Nausea (feeling of having an urge to vomit)
  2. Vomiting

30-39:

  1. Anxiety
  2. Dehydration (dryness resulting from the removal of water)
  3. Dental caries
  4. Exposure to toxic agent
  5. Insomnia (sleeplessness)
  6. Panic attack

40-49:

  1. Back pain
  2. Arthralgia (joint pain)
  3. Blood urine present
  4. Bone pain
  5. Chronic sinusitis (long lasting inflammation of the paranasal sinuses)
  6. Dehydration (dryness resulting from the removal of water)
  7. Facial pain
  8. Fungal infection
  9. Gastrointestinal viral infection (virus infection of gastrointestinal tract)
  10. Headache (pain in head)

50-59:

  1. Abdominal neoplasm (cancer of the stomach)
  2. Asthma
  3. Oesophageal adenocarcinoma (a cancer tumour of an epithelium in oesophagus)
  4. Pneumonia

60+:

  1. Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
  2. Drug ineffective
  3. Hypotension (abnormally low blood pressure)
  4. Paranoia (psychotic disorder characterized by delusions of persecution with or without grandeur)
  5. Skin infection
  6. Weight decreased

What are the existing conditions these people have? *

  1. Immunodeficiency Common Variable: 4 people, 28.57%
  2. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 14.29%
  3. Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 14.29%
  4. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 7.14%
  5. Pain: 1 person, 7.14%
  6. Major Depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings): 1 person, 7.14%
  7. Diabetes: 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Methylphenidate hydrochloride and Mirapex?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Methylphenidate hydrochloride and Mirapex:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Methylphenidate hydrochloride:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Mirapex:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Methylphenidate hydrochloride and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Mirapex and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on methylphenidate hydrochloride and pramipexole dihydrochloride (the active ingredients of Methylphenidate hydrochloride and Mirapex, respectively), and Methylphenidate hydrochloride and Mirapex (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

Recent studies on eHealthMe:

© 2026 eHealthMe.com. All rights reserved. Use of this site constitutes acceptance of eHealthMe.com's terms of service and privacy policy.