Methylphenidate and Nexplanon drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Methylphenidate (methylphenidate) and Nexplanon (etonogestrel). Common drug interactions include menorrhagia among females.

The phase IV clinical study analyzes what interactions people have when they take Methylphenidate and Nexplanon. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Methylphenidate?

Methylphenidate has active ingredients of methylphenidate. eHealthMe is studying from 8,216 Methylphenidate users. Check the latest studies of Methylphenidate.

What is Nexplanon?

Nexplanon has active ingredients of etonogestrel. It is often used in birth control. eHealthMe is studying from 46,431 Nexplanon users. Check the latest studies of Nexplanon.



On Jul, 11, 2026

13 people who take Methylphenidate and Nexplanon together, and have interactions are studied.

Methylphenidate and Nexplanon drug interactions.

What are the common drug interactions of Methylphenidate and Nexplanon, by gender? *:

female:

  1. Menorrhagia (an abnormally heavy bleeding and prolonged menstrual period at regular intervals)
  2. Rash
  3. Dry mouth
  4. Dysgeusia (disorder of the sense of taste)
  5. Dysmenorrhoea (painful menstruation)
  6. Dyspepsia (indigestion)
  7. Fall
  8. Fibromyalgia (a long-term condition which causes pain all over the body)
  9. Haemorrhage (bleeding)
  10. Hysterectomy

male:

n/a

What are the common drug interactions of Methylphenidate and Nexplanon, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

  1. Loss of consciousness

20-29:

  1. Blood pressure increased
  2. Decreased appetite
  3. Dizziness
  4. Dry mouth
  5. Palpitations (feelings or sensations that your heart is pounding or racing)
  6. Pruritus (severe itching of the skin)
  7. Rash
  8. Swelling face
  9. Weight decreased

30-39:

  1. Dysmenorrhoea (painful menstruation)
  2. Fibromyalgia (a long-term condition which causes pain all over the body)
  3. Hysterectomy
  4. Menorrhagia (an abnormally heavy bleeding and prolonged menstrual period at regular intervals)

40-49:

  1. Dysgeusia (disorder of the sense of taste)
  2. Fall
  3. Vulvovaginal pain
  4. Haemorrhage (bleeding)
  5. Menorrhagia (an abnormally heavy bleeding and prolonged menstrual period at regular intervals)
  6. Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
  7. Pyrexia (fever)
  8. Rash
  9. Retching (strong involuntary effort to vomit)
  10. Road traffic accident

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

  1. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 7 people, 53.85%
  2. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 4 people, 30.77%
  3. Seasonal Allergy (allergic condition due to certain season): 1 person, 7.69%
  4. Muscle Spasms (muscle contraction): 1 person, 7.69%
  5. Hyperhidrosis (abnormally increased sweating): 1 person, 7.69%
  6. Depression: 1 person, 7.69%
  7. Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Methylphenidate and Nexplanon?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Methylphenidate and Nexplanon:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Methylphenidate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Nexplanon:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Methylphenidate and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Nexplanon and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on methylphenidate and etonogestrel (the active ingredients of Methylphenidate and Nexplanon, respectively), and Methylphenidate and Nexplanon (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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