Metra and Metformin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Metra (phendimetrazine tartrate) and Metformin (metformin hydrochloride). Common drug interactions include sudden cardiac death among females and drug ineffective among males.

The phase IV clinical study analyzes what interactions people have when they take Metra and Metformin. It is created by eHealthMe based on reports of 38 people who take the same drugs from the FDA, and is updated regularly.

What is Metra?

Metra has active ingredients of phendimetrazine tartrate. eHealthMe is studying from 505 Metra users. Check the latest studies of Metra.

What is Metformin?

Metformin has active ingredients of metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 465,354 Metformin users. Check the latest studies of Metformin.

On Jul, 26, 2026

38 people who take Metra and Metformin together, and have interactions are studied.

What are the common drug interactions of Metra and Metformin, by gender? *:

female:

Sudden cardiac death
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Respiratory distress (difficulty in breathing)
Chronic kidney disease
Drug ineffective
Myocardial fibrosis (a condition in which the heart's muscle cells are impaired)
Pain
Cell death
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Fatigue (feeling of tiredness)

male:

Drug ineffective
Sudden cardiac death
Myocarditis (inflammation of heart muscle myocardium)
Pain in extremity
Sudden death
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
Cardiac hypertrophy (thickening of the heart muscle)
Cardiomyopathy (weakening of the heart muscle)
Gait disturbance
Hypersensitivity

What are the common drug interactions of Metra and Metformin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Sudden cardiac death
Myocardial fibrosis (a condition in which the heart's muscle cells are impaired)
Cell death
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Myocarditis (inflammation of heart muscle myocardium)
Ventricular hypertrophy (enlargement of ventricles (lower chambers) in the heart)

30-39:

Sudden cardiac death
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
Cardiac hypertrophy (thickening of the heart muscle)
Cardiomyopathy (weakening of the heart muscle)
Myocardial fibrosis (a condition in which the heart's muscle cells are impaired)
Myocardial ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased)
Myocarditis (inflammation of heart muscle myocardium)
Sudden death

40-49:

Chronic kidney disease
Pulmonary embolism (blockage of the main artery of the lung)

50-59:

Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Respiratory distress (difficulty in breathing)
Asthenia (weakness)
Concussion (short loss of normal brain function in response to a head injury)
Fall
Fatigue (feeling of tiredness)
Influenza
Malaise (a feeling of general discomfort or uneasiness)
Neuropathy peripheral (surface nerve damage)
Pain

60+:

Drug ineffective
Chronic kidney disease
Pain
Pain in extremity
Renal failure (kidney dysfunction)
Decreased appetite
Diarrhoea
Drug effect decreased
Gait disturbance
Hypoaesthesia (reduced sense of touch or sensation)

What are the existing conditions these people have? *

Weight Loss: 11 people, 28.95%
High Blood Pressure: 10 people, 26.32%
Pain: 8 people, 21.05%
High Blood Cholesterol: 7 people, 18.42%
Stress And Anxiety: 7 people, 18.42%
Neuralgia (pain in one or more nerves): 6 people, 15.79%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 6 people, 15.79%
Type 2 Diabetes: 5 people, 13.16%
Indigestion: 5 people, 13.16%
Diabetic Neuropathy (neuropathic disorders that are associated with diabetes mellitus): 5 people, 13.16%

* Approximation only. Some reports may have incomplete information.

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