Microzide and Profen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Microzide (hydrochlorothiazide) and Profen (ibuprofen). Common drug interactions include immediate post-injection reaction among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Microzide and Profen. It is created by eHealthMe based on reports of 34 people who take the same drugs from the FDA, and is updated regularly.

What is Microzide?

Microzide has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 994 Microzide users. Check the latest studies of Microzide.

What is Profen?

Profen has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 245,311 Profen users. Check the latest studies of Profen.

On Aug, 06, 2026

34 people who take Microzide and Profen together, and have interactions are studied.

What are the common drug interactions of Microzide and Profen, by gender? *:

female:

Immediate post-injection reaction
Injection site erythema (redness at injection site)
Injection site pruritus (severe itching at injection site)
Injection site swelling
Injection site warmth
Lip swelling
Malignant neoplasm progression (cancer tumour came back)
Mastoiditis (infection of mastoid bone)
Meningioma (a diverse set of tumours arising from the meninges)
Oedema peripheral (superficial swelling)

male:

Anxiety
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Abdominal pain
Anaemia (lack of blood)
Arthralgia (joint pain)
Back injury
Blindness
Blood sodium decreased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Chest pain

What are the common drug interactions of Microzide and Profen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Overdose
Respiratory depression (respiration has a rate below 12 breaths)
Somnolence (a state of near-sleep, a strong desire for sleep)
Weight increased

40-49:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Emotional distress
Palpitations (feelings or sensations that your heart is pounding or racing)
Proteinuria (presence of protein in the urine)
Renal disorder (kidney disease)
Renal impairment (severely reduced kidney function)
Ventricular extrasystoles (premature cardiac contraction)
Oropharyngeal pain

50-59:

Back injury
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Chronic kidney disease
Contusion (a type of hematoma of tissue in which capillaries)
Fall
Feeling hot
Haematoma (collection of blood outside the blood vessels)
Lumbar vertebral fracture
Pericardial effusion malignant (cancerous fluid around the heart)
Renal failure (kidney dysfunction)

60+:

Chronic kidney disease
Renal failure (kidney dysfunction)
Metastases to lymph nodes (cancer spreads to lymph node)
Metastases to pancreas (cancer spreads to pancreas)
Metastases to spleen (cancer spreads to spleen)
Metastatic malignant melanoma (spreadable cancer tumour of melanine)
Nausea (feeling of having an urge to vomit)
Pericardial effusion (fluid around the heart)
Swelling face
Anaemia (lack of blood)

What are the existing conditions these people have? *

Nausea (feeling of having an urge to vomit): 8 people, 23.53%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 17.65%
Muscle Spasms (muscle contraction): 5 people, 14.71%
Stress And Anxiety: 4 people, 11.76%
Infection: 4 people, 11.76%
Metastatic Malignant Melanoma (spreadable cancer tumour of melanine): 3 people, 8.82%
Fever: 3 people, 8.82%
High Blood Cholesterol: 3 people, 8.82%
Hypersensitivity: 3 people, 8.82%
Itching: 3 people, 8.82%

* Approximation only. Some reports may have incomplete information.

Do you take Microzide and Profen?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously