Midodrine hydrochloride and Adderall drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Midodrine hydrochloride (midodrine hydrochloride) and Adderall (amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate). Common drug interactions include sleep-related eating disorder among females and drug ineffective among males.

The phase IV clinical study analyzes what interactions people have when they take Midodrine hydrochloride and Adderall. It is created by eHealthMe based on reports of 55 people who take the same drugs from the FDA, and is updated regularly.

What is Midodrine hydrochloride?

Midodrine hydrochloride has active ingredients of midodrine hydrochloride. It is often used in hypotension. eHealthMe is studying from 3,274 Midodrine hydrochloride users. Check the latest studies of Midodrine hydrochloride.

What is Adderall?

Adderall has active ingredients of amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 64,224 Adderall users. Check the latest studies of Adderall.

On Jul, 14, 2026

55 people who take Midodrine hydrochloride and Adderall together, and have interactions are studied.

Midodrine hydrochloride and Adderall drug interactions.

What are the common drug interactions of Midodrine Hydrochloride and Adderall, by gender? *:

female:

Sleep-related eating disorder (abnormal eating patterns during the night)
Hyperthyroidism (over activity of the thyroid gland)
Heart rate increased
Pruritus (severe itching of the skin)
Road traffic accident
Surgery
Ankle fracture
Hypersensitivity
Muscle spasms (muscle contraction)
Drug ineffective

male:

Drug ineffective
Abdominal discomfort
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Somnolence (a state of near-sleep, a strong desire for sleep)
Spinal stenosis (narrowing of spinal column)
Abnormal loss of weight
Diarrhoea
Dizziness
Dyspnoea (difficult or laboured respiration)
Heart rate increased

What are the common drug interactions of Midodrine Hydrochloride and Adderall, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Drug ineffective
Affective disorder (mental disorder)
Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi)
Coeliac disease (simple food intolerance)
Cold sweat
Fibromyalgia (a long-term condition which causes pain all over the body)
Seasonal allergy (allergic condition due to certain season)
Suicidal ideation
Abdominal discomfort
Abnormal loss of weight

20-29:

Hyperthyroidism (over activity of the thyroid gland)
Pruritus (severe itching of the skin)
Road traffic accident
Sleep-related eating disorder (abnormal eating patterns during the night)
Surgery
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Anxiety
Back injury
Craniocerebral injury (injury to cranium and brain)
Neck pain

30-39:

Asthma
Stress

40-49:

Hyperthyroidism (over activity of the thyroid gland)
Initial insomnia (feeling of inadequate or poor-quality sleep)
Seasonal allergy (allergic condition due to certain season)

50-59:

Autonomic failure syndrome (a degenerative disease of the autonomic nervous system)
Back pain
Cervical radiculopathy (disturbance of nerve function that causes pain in the upper body)
Chest pain
Eye pain
Glaucoma (increased fluid pressure in the eye with vision loss)
Intervertebral disc degeneration (spinal disc degeneration)
Muscle spasms (muscle contraction)
Nerve compression
Nerve injury

60+:

Abdominal discomfort
Autoimmune thyroiditis (form of thyroiditis associated with an autoimmune disease)
Sepsis (a severe blood infection that can lead to organ failure and death)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Diarrhoea
Facial bones fracture (bone fracture of face)
Fall
Macular degeneration (painless eye condition that leads to the gradual loss of central vision)
Osteopenia (a condition where bone mineral density is lower than normal)
Pneumonia

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 37 people, 67.27%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 28 people, 50.91%
Drowsiness: 20 people, 36.36%
Neuralgia (pain in one or more nerves): 5 people, 9.09%
Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 5 people, 9.09%
Immune System Disorder: 4 people, 7.27%

* Approximation only. Some reports may have incomplete information.

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