Modafinil and Niacin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Modafinil (modafinil) and Niacin (niacin). Common drug interactions include chest discomfort among females and atrial fibrillation among males.

The phase IV clinical study analyzes what interactions people have when they take Modafinil and Niacin. It is created by eHealthMe based on reports of 35 people who take the same drugs from the FDA, and is updated regularly.

What is Modafinil?

Modafinil has active ingredients of modafinil. It is often used in narcolepsy. eHealthMe is studying from 20,805 Modafinil users. Check the latest studies of Modafinil.

What is Niacin?

Niacin has active ingredients of niacin. It is often used in high blood cholesterol. eHealthMe is studying from 9,008 Niacin users. Check the latest studies of Niacin.

On Jul, 19, 2026

35 people who take Modafinil and Niacin together, and have interactions are studied.

What are the common drug interactions of Modafinil and Niacin, by gender? *:

female:

Chest discomfort
Cholecystitis (infection of gallbladder)
Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Dyspepsia (indigestion)
Flushing (the warm, red condition of human skin)
Intervertebral disc degeneration (spinal disc degeneration)
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Retinopathy hypertensive (acute damage to the retina of the eye due to high blood pressure)

male:

Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Essential hypertension (primary hypertension)
Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve)
Abdominal pain
Akathisia (a movement disorder characterized by a feeling of inner restlessness)
Anaemia (lack of blood)
Anxiety
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)
Autoimmune disorder (a condition in which the immune system attacks the body's normal substances and tissue)

What are the common drug interactions of Modafinil and Niacin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Hepatitis c
Insomnia (sleeplessness)
Obesity (having too much body fat)
Cholecystitis (infection of gallbladder)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Acne (skin problems that cause pimples)
Alopecia (absence of hair from areas of the body)
Anaemia (lack of blood)
Diabetes mellitus non-insulin-dependent

40-49:

n/a

50-59:

Drug screen positive
Dysphonia (speech disorder attributable to a disorder of phonation)
Fall
Fatigue (feeling of tiredness)
Haemoglobin decreased
Intervertebral disc degeneration (spinal disc degeneration)
Ligament sprain (ligament stretched)
Limb injury
Lipase increased
Myalgia (muscle pain)

60+:

Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Intervertebral disc protrusion (spinal disc protrusion)
Metastases to lymph nodes (cancer spreads to lymph node)
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Neuralgia (pain in one or more nerves)
Restless legs syndrome (a powerful urge to move your legs)
Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve)
Syncope (loss of consciousness with an inability to maintain postural tone)

What are the existing conditions these people have? *

Cataplexy (loss of muscle tone accompanied by full conscious awareness): 13 people, 37.14%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 11 people, 31.43%
Drowsiness: 9 people, 25.71%
Insomnia (sleeplessness): 4 people, 11.43%
Bipolar Disorder (mood disorder): 3 people, 8.57%
Bladder Cancer: 2 people, 5.71%

* Approximation only. Some reports may have incomplete information.

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