Modafinil and Restoril drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Modafinil (modafinil) and Restoril (temazepam). Common drug interactions include pain in extremity among females and abdominal pain upper among males.
The phase IV clinical study analyzes what interactions people have when they take Modafinil and Restoril. It is created by eHealthMe based on reports of 25 people who take the same drugs from the FDA, and is updated regularly.
What is Modafinil?
Modafinil has active ingredients of modafinil. It is often used in narcolepsy. eHealthMe is studying from 20,805 Modafinil users. Check the latest studies of Modafinil.
What is Restoril?
Restoril has active ingredients of temazepam. It is often used in insomnia. eHealthMe is studying from 13,522 Restoril users. Check the latest studies of Restoril.
25 people who take Modafinil and Restoril together, and have interactions are studied.

What are the common drug interactions of Modafinil and Restoril, by gender? *:
female:
- Pain in extremity
- Weight decreased
- Back disorder
- Blood glucose decreased
- Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
- Dysphonia (speech disorder attributable to a disorder of phonation)
- Flushing (the warm, red condition of human skin)
- Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
- General physical health deterioration (weak health status)
- Hot flush (sudden feelings of heat)
male:
- Abdominal pain upper
- Cardiac disorder
- Pneumonia
- Sepsis (a severe blood infection that can lead to organ failure and death)
- Tremor (trembling or shaking movements in one or more parts of your body)
- Urinary tract infection
- Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
- Confusional state
- Constipation
- Decubitus ulcer (a chronic ulcer of the skin caused by prolonged pressure on it)
What are the common drug interactions of Modafinil and Restoril, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
n/a
10-19:
n/a
20-29:
- Abdominal pain upper
- Depression
- Nausea (feeling of having an urge to vomit)
- Tremor (trembling or shaking movements in one or more parts of your body)
30-39:
- Gallbladder operation
40-49:
- Flushing (the warm, red condition of human skin)
- Hot flush (sudden feelings of heat)
- Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
- Drug withdrawal convulsions
- Dyspepsia (indigestion)
- Haemorrhage (bleeding)
- Hysterectomy
- Memory impairment
- Rash
- Sensory disturbance (sense disturbance)
50-59:
- Influenza like illness
- Malaise (a feeling of general discomfort or uneasiness)
- Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking)
- Memory impairment
- Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
- Pneumonia
- Sepsis (a severe blood infection that can lead to organ failure and death)
- Urinary tract infection
- Asthenia (weakness)
- Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
60+:
- Burning sensation
- Hypoaesthesia (reduced sense of touch or sensation)
- Migraine (headache)
- Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
- Neuropathy peripheral (surface nerve damage)
- Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
What are the existing conditions these people have? *
- Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 10 people, 40.00%
- Primary Immunodeficiency Syndrome: 3 people, 12.00%
- Immunodeficiency Common Variable: 3 people, 12.00%
- Drowsiness: 2 people, 8.00%
- Cataplexy (loss of muscle tone accompanied by full conscious awareness): 2 people, 8.00%
* Approximation only. Some reports may have incomplete information.
Do you take Modafinil and Restoril?
- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously
Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
Browse all drug interactions of Modafinil and Restoril:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Modafinil:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Restoril:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Modafinil and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Restoril and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- Lopes E, Pereira D, da Silva Behrens NS, de Almeida Fonseca H, Calvancanti PO, de Araújo Lima TF, Pradella-Hallinan M, Castro J, Tufik S, Coelho FM, "Cataplexy as a side effect of modafinil in a patient without narcolepsy", Sleep Science, 2014 Mar .
- Lopes E, Pereira D, da Silva Behrens NS, de Almeida Fonseca H, Calvancanti PO, de Araújo Lima TF, Pradella-Hallinan M, Castro J, Tufik S, Coelho FM, "Cataplexy as a side effect of modafinil in a patient without narcolepsy", Sleep Science, 2014 Mar .
How the study uses the data?
The study uses data from the FDA. It is based on modafinil and temazepam (the active ingredients of Modafinil and Restoril, respectively), and Modafinil and Restoril (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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