Modafinil and Sinemet drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Modafinil (modafinil) and Sinemet (carbidopa; levodopa). Common drug interactions include amnesia among females and dyspepsia among males.

The phase IV clinical study analyzes what interactions people have when they take Modafinil and Sinemet. It is created by eHealthMe based on reports of 88 people who take the same drugs from the FDA, and is updated regularly.

What is Modafinil?

Modafinil has active ingredients of modafinil. It is often used in narcolepsy. eHealthMe is studying from 20,805 Modafinil users. Check the latest studies of Modafinil.

What is Sinemet?

Sinemet has active ingredients of carbidopa; levodopa. It is often used in parkinson's disease. eHealthMe is studying from 29,601 Sinemet users. Check the latest studies of Sinemet.

On Jul, 12, 2026

88 people who take Modafinil and Sinemet together, and have interactions are studied.

Modafinil and Sinemet drug interactions.

What are the common drug interactions of Modafinil and Sinemet, by gender? *:

female:

Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Back pain
Blood pressure decreased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Burning sensation
Candidiasis (candidiasis or thrush is a fungal infection)
Cheilitis (infection of lips)
Chills (felling of cold)
Dementia (madness)

male:

Dyspepsia (indigestion)
Anxiety
Claustrophobia (fear of having no escape and being closed in small spaces)
Cough
Emotional distress
Erectile dysfunction
Fatigue (feeling of tiredness)
Gastric ulcer (stomach ulcer)
Glossodynia (a burning or painful sensation in the tongue)
Hypertonic bladder (bladder-storage function that causes a sudden urge to urinate)

What are the common drug interactions of Modafinil and Sinemet, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Vomiting

20-29:

n/a

30-39:

Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Asthenia (weakness)
Atelectasis (partial or complete collapse of the lung)
Extremity contracture (permanent shortening of a muscle or joint of arms and legs)
Facial paralysis (loss of function of face muscle)
Fall
Hypertonia (abnormal increase in muscle tension and a reduced ability of a muscle to stretch)
Joint effusion (presence of extra fluid in joint covering)
Joint injury
Joint swelling

40-49:

n/a

50-59:

Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Burning sensation
Depression
Dizziness
Facial spasm (involuntary muscle contractions face)
Gait disturbance
Hallucination (an experience involving the perception of something not present)
Loss of employment
Marital problem
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)

60+:

Fall
Memory impairment
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chest pain
Drug ineffective
Dyspepsia (indigestion)
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Yawning (simultaneous inhalation of air and stretching of the eardrums, followed by exhalation of breath)
Cardiac flutter (abnormal heart rhythm)
Dyspnoea (difficult or laboured respiration)

What are the existing conditions these people have? *

Cataplexy (loss of muscle tone accompanied by full conscious awareness): 20 people, 22.73%
Drowsiness: 19 people, 21.59%
High Blood Pressure: 11 people, 12.50%
Hallucinations (sensations that appear real but are created by your mind): 10 people, 11.36%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 10 people, 11.36%
Insomnia (sleeplessness): 8 people, 9.09%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 8 people, 9.09%
Delusion (a false belief or opinion): 8 people, 9.09%
Urinary Tract Infection: 7 people, 7.95%
Hypertonic Bladder (bladder-storage function that causes a sudden urge to urinate): 7 people, 7.95%

* Approximation only. Some reports may have incomplete information.

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