Morphine sulfate and Invokana drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Morphine sulfate (morphine sulfate) and Invokana (canagliflozin). Common drug interactions include thyroid disorder among females and abdominal pain among males.

The phase IV clinical study analyzes what interactions people have when they take Morphine sulfate and Invokana. It is created by eHealthMe based on reports of 60 people who take the same drugs from the FDA, and is updated regularly.

What is Morphine sulfate?

Morphine sulfate has active ingredients of morphine sulfate. It is often used in pain. eHealthMe is studying from 87,261 Morphine sulfate users. Check the latest studies of Morphine sulfate.

What is Invokana?

Invokana has active ingredients of canagliflozin. It is often used in diabetes. eHealthMe is studying from 29,937 Invokana users. Check the latest studies of Invokana.



On Jul, 30, 2026

60 people who take Morphine sulfate and Invokana together, and have interactions are studied.

Morphine sulfate and Invokana drug interactions.

What are the common drug interactions of Morphine Sulfate and Invokana, by gender? *:

female:

  1. Thyroid disorder (thyroid diseases)
  2. Urinary tract infection
  3. Weight decreased
  4. Abdominal discomfort
  5. Abdominal pain upper
  6. Cellulitis (infection under the skin)
  7. Chest pain
  8. Chronic kidney disease
  9. Constipation
  10. Erythema (redness of the skin)

male:

  1. Abdominal pain
  2. Blood pressure systolic increased
  3. Myalgia (muscle pain)
  4. Death
  5. Neuropathy peripheral (surface nerve damage)
  6. Arthralgia (joint pain)
  7. Blood pressure fluctuation
  8. Chronic kidney disease
  9. Gait disturbance
  10. Emotional distress

What are the common drug interactions of Morphine Sulfate and Invokana, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

  1. Dysuria (painful or difficult urination)
  2. Nocturia (the need to get up in the night to urinate)
  3. Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
  4. Renal pain (kidney pain)
  5. Balanoposthitis (inflammation of the glands penis and the foreskin)
  6. Dehydration (dryness resulting from the removal of water)

40-49:

  1. Weight decreased
  2. Neuropathy peripheral (surface nerve damage)
  3. Chronic kidney disease
  4. Gait disturbance
  5. Emotional distress
  6. Staphylococcal infection (an infection with staphylococcus bacteria)
  7. Back disorder
  8. Renal failure (kidney dysfunction)
  9. Abscess limb (limb infection)
  10. Anal abscess

50-59:

  1. Abdominal discomfort
  2. Abdominal pain upper
  3. Anti factor viii antibody positive
  4. Constipation
  5. Drug hypersensitivity
  6. Thrombosis (formation of a blood clot inside a blood vessel)
  7. Urinary tract infection
  8. Vomiting

60+:

  1. Pain in extremity
  2. Abdominal pain
  3. Blood pressure increased
  4. Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
  5. Fall
  6. Myalgia (muscle pain)
  7. Neoplasm progression (growth of tumour)
  8. Platelet count decreased
  9. Red blood cell count decreased
  10. White blood cell count decreased

What are the existing conditions these people have? *

  1. Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 15 people, 25.00%
  2. Back Pain: 15 people, 25.00%
  3. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 9 people, 15.00%
  4. Depression: 6 people, 10.00%
  5. Type 2 Diabetes: 5 people, 8.33%
  6. Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 4 people, 6.67%
  7. High Blood Pressure: 4 people, 6.67%
  8. Breast Cancer Metastatic: 4 people, 6.67%
  9. Sleep Disorder: 3 people, 5.00%
  10. Muscle Spasms (muscle contraction): 3 people, 5.00%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Morphine sulfate and Invokana:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Morphine sulfate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Invokana:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Morphine sulfate and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Invokana and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on morphine sulfate and canagliflozin (the active ingredients of Morphine sulfate and Invokana, respectively), and Morphine sulfate and Invokana (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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