Morphine and Iopidine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Morphine (morphine sulfate) and Iopidine (apraclonidine hydrochloride). Common drug interactions include dizziness among females and bone pain among males.

The phase IV clinical study analyzes what interactions people have when they take Morphine and Iopidine. It is created by eHealthMe based on reports of 24 people who take the same drugs from the FDA, and is updated regularly.

What is Morphine?

Morphine has active ingredients of morphine sulfate. It is often used in pain. eHealthMe is studying from 182,913 Morphine users. Check the latest studies of Morphine.

What is Iopidine?

Iopidine has active ingredients of apraclonidine hydrochloride. eHealthMe is studying from 394 Iopidine users. Check the latest studies of Iopidine.



On Jul, 28, 2026

24 people who take Morphine and Iopidine together, and have interactions are studied.

Morphine and Iopidine drug interactions.

What are the common drug interactions of Morphine and Iopidine, by gender? *:

female:

  1. Dizziness
  2. Ejection fraction decreased (systolic heart failure)
  3. Fatigue (feeling of tiredness)
  4. Nausea (feeling of having an urge to vomit)
  5. Osteopenia (a condition where bone mineral density is lower than normal)
  6. Pleural effusion (water on the lungs)
  7. Presyncope
  8. Rectal haemorrhage (bleeding from anus)
  9. Weight decreased
  10. Headache (pain in head)

male:

  1. Bone pain
  2. Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
  3. Diabetes mellitus inadequate control
  4. Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)

What are the common drug interactions of Morphine and Iopidine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

  1. Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
  2. Drug intolerance (drug sensitivity)
  3. Injection site reaction
  4. Vaginal infection

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

  1. Diarrhoea
  2. Retinal detachment (a disorder of the eye in which the retina peels away from its underlying layer of support tissue)
  3. Osteopenia (a condition where bone mineral density is lower than normal)
  4. Pleural effusion (water on the lungs)
  5. Presyncope
  6. Rectal haemorrhage (bleeding from anus)
  7. Weight decreased
  8. Headache (pain in head)
  9. Bone pain
  10. Bronchitis (inflammation of the mucous membrane in the bronchial tubes)

What are the existing conditions these people have? *

  1. Urinary Tract Infection: 17 people, 70.83%
  2. Osteopenia (a condition where bone mineral density is lower than normal): 17 people, 70.83%
  3. Pleural Effusion (water on the lungs): 16 people, 66.67%
  4. Ejection Fraction Decreased (systolic heart failure): 16 people, 66.67%
  5. Dyspnea (difficult or laboured breathing): 16 people, 66.67%
  6. Breast Cancer: 16 people, 66.67%
  7. Back Pain: 16 people, 66.67%
  8. Breast Cancer Metastatic: 14 people, 58.33%
  9. Retinal Detachment (a disorder of the eye in which the retina peels away from its underlying layer of support tissue): 8 people, 33.33%
  10. Diarrhea: 7 people, 29.17%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Morphine and Iopidine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Morphine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Iopidine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Morphine and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Iopidine and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on morphine sulfate and apraclonidine hydrochloride (the active ingredients of Morphine and Iopidine, respectively), and Morphine and Iopidine (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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