Motegrity and Profen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Motegrity (prucalopride succinate) and Profen (ibuprofen). Common drug interactions include migraine among females and death among males.

The phase IV clinical study analyzes what interactions people have when they take Motegrity and Profen. It is created by eHealthMe based on reports of 29 people who take the same drugs from the FDA, and is updated regularly.

What is Motegrity?

Motegrity has active ingredients of prucalopride succinate. eHealthMe is studying from 1,380 Motegrity users. Check the latest studies of Motegrity.

What is Profen?

Profen has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 245,311 Profen users. Check the latest studies of Profen.

On Jul, 20, 2026

29 people who take Motegrity and Profen together, and have interactions are studied.

What are the common drug interactions of Motegrity and Profen, by gender? *:

female:

Migraine (headache)
Asthma
Constipation
Foot fracture
Hypoaesthesia (reduced sense of touch or sensation)
Neuroma (tumour of nerve tissue)
Pain in extremity
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Pruritus (severe itching of the skin)
Urticaria (rash of round, red welts on the skin that itch intensely)

male:

Death
Dizziness
Dyspnoea (difficult or laboured respiration)
Hallucination (an experience involving the perception of something not present)
Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up)
Somnolence (a state of near-sleep, a strong desire for sleep)
Sputum discoloured

What are the common drug interactions of Motegrity and Profen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Asthma
Foot fracture
Hypoaesthesia (reduced sense of touch or sensation)
Ligament sprain (ligament stretched)
Lyme disease (a bacterial infection that is spread to humans by infected ticks)
Neuroma (tumour of nerve tissue)
Pain in extremity
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Pruritus (severe itching of the skin)
Urticaria (rash of round, red welts on the skin that itch intensely)

30-39:

n/a

40-49:

Headache (pain in head)
Fungal infection
Abdominal pain upper
Pancreatitis (inflammation of pancreas)
Viral pharyngitis (inflammation of the throat or pharynx caused by viral infection)
Malaise (a feeling of general discomfort or uneasiness)
Migraine (headache)
Nausea (feeling of having an urge to vomit)
Vomiting
Abdominal discomfort

50-59:

Drug ineffective
Death
Injection site necrosis (death of body tissue at injection site)
Muscle atrophy (a decrease in the mass of the muscle)
Post procedural complication

60+:

Dizziness
Myalgia (muscle pain)
Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up)
Somnolence (a state of near-sleep, a strong desire for sleep)
Sputum discoloured
Vomiting
Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)
Diarrhoea
Dyspnoea (difficult or laboured respiration)
Ear discomfort

What are the existing conditions these people have? *

Dermatomyositis (inflammation of the skin and underlying muscle tissue, typically occurring as an autoimmune condition or associated with internal cancer): 6 people, 20.69%
Impaired Gastric Emptying: 4 people, 13.79%
Immunodeficiency Common Variable: 4 people, 13.79%
Autonomic Neuropathy (malfunction of the autonomic nervous system (ans)): 4 people, 13.79%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 10.34%
Colon Cancer: 2 people, 6.90%

* Approximation only. Some reports may have incomplete information.

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