Mydriacyl and Methotrexate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Mydriacyl (tropicamide) and Methotrexate (methotrexate sodium). Common drug interactions include uveitis among females and encephalitis among males.

The phase IV clinical study analyzes what interactions people have when they take Mydriacyl and Methotrexate. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Mydriacyl?

Mydriacyl has active ingredients of tropicamide. eHealthMe is studying from 398 Mydriacyl users. Check the latest studies of Mydriacyl.

What is Methotrexate?

Methotrexate has active ingredients of methotrexate sodium. It is often used in rheumatoid arthritis. eHealthMe is studying from 604,312 Methotrexate users. Check the latest studies of Methotrexate.



On Jul, 14, 2026

13 people who take Mydriacyl and Methotrexate together, and have interactions are studied.

Mydriacyl and Methotrexate drug interactions.

What are the common drug interactions of Mydriacyl and Methotrexate, by gender? *:

female:

  1. Uveitis (inflammation of the uvea)
  2. Encephalitis (inflammation of the brain)
  3. Fatigue (feeling of tiredness)
  4. Gait disturbance
  5. Glaucoma (increased fluid pressure in the eye with vision loss)
  6. Headache (pain in head)
  7. Neck pain
  8. Respiratory failure (inadequate gas exchange by the respiratory system)
  9. Upper extremity mass
  10. Varicella

male:

  1. Encephalitis (inflammation of the brain)
  2. Pyrexia (fever)
  3. Pneumonia herpes viral (herpes simplex virus pneumonia:)
  4. Respiratory failure (inadequate gas exchange by the respiratory system)
  5. Varicella
  6. Cataract (clouding of the lens inside the eye)
  7. Disseminated intravascular coagulation (systemic activation of blood coagulation)
  8. Intracranial pressure increased (high pressure inside the skull and thus in the brain tissue and cerebrospinal fluid)

What are the common drug interactions of Mydriacyl and Methotrexate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

  1. Encephalitis (inflammation of the brain)
  2. Respiratory failure (inadequate gas exchange by the respiratory system)
  3. Varicella
  4. Disseminated intravascular coagulation (systemic activation of blood coagulation)
  5. Intracranial pressure increased (high pressure inside the skull and thus in the brain tissue and cerebrospinal fluid)
  6. Pneumonia herpes viral (herpes simplex virus pneumonia:)

10-19:

  1. Pyrexia (fever)
  2. Cataract (clouding of the lens inside the eye)

20-29:

n/a

30-39:

n/a

40-49:

  1. Upper extremity mass
  2. Varicella
  3. Encephalitis (inflammation of the brain)
  4. Fatigue (feeling of tiredness)
  5. Gait disturbance
  6. Headache (pain in head)
  7. Neck pain
  8. Respiratory failure (inadequate gas exchange by the respiratory system)

50-59:

n/a

60+:

  1. Eye swelling
  2. Visual impairment
  3. Uveitis (inflammation of the uvea)
  4. Glaucoma (increased fluid pressure in the eye with vision loss)

What are the existing conditions these people have? *

  1. Uveitis (inflammation of the uvea): 5 people, 38.46%
  2. Glaucoma (increased fluid pressure in the eye with vision loss): 5 people, 38.46%
  3. Intraocular Pressure Increased: 3 people, 23.08%
  4. Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 3 people, 23.08%
  5. Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Mydriacyl and Methotrexate?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Mydriacyl and Methotrexate:

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Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Mydriacyl:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Methotrexate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Mydriacyl and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Methotrexate and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on tropicamide and methotrexate sodium (the active ingredients of Mydriacyl and Methotrexate, respectively), and Mydriacyl and Methotrexate (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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