Naltrexone hydrochloride and Simvastatin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Naltrexone hydrochloride (naltrexone hydrochloride) and Simvastatin (simvastatin). Common drug interactions include splenic lesion among females and hepatocellular injury among males.

The phase IV clinical study analyzes what interactions people have when they take Naltrexone hydrochloride and Simvastatin. It is created by eHealthMe based on reports of 24 people who take the same drugs from the FDA, and is updated regularly.

What is Naltrexone hydrochloride?

Naltrexone hydrochloride has active ingredients of naltrexone hydrochloride. It is often used in alcoholism. eHealthMe is studying from 1,712 Naltrexone hydrochloride users. Check the latest studies of Naltrexone hydrochloride.

What is Simvastatin?

Simvastatin has active ingredients of simvastatin. It is often used in high blood cholesterol. eHealthMe is studying from 256,969 Simvastatin users. Check the latest studies of Simvastatin.

On Jul, 17, 2026

24 people who take Naltrexone hydrochloride and Simvastatin together, and have interactions are studied.

Naltrexone hydrochloride and Simvastatin drug interactions.

What are the common drug interactions of Naltrexone Hydrochloride and Simvastatin, by gender? *:

female:

Splenic lesion (lesion on spleen)
Spondylolisthesis (displacement of a vertebra or the vertebral column in relation to the vertebrae below)
Spondylolysis (a defect of a vertebra)
Synovial cyst (cyst of joint filled with synovial fluid)
Tinnitus (a ringing in the ears)
Tongue discolouration (colour change of tongue)
Vaginal discharge
Vertebral foraminal stenosis (narrowing of the intervertebral foramen)
Viral infection
Visual impairment

male:

Hepatocellular injury (liver injury)
Altered state of consciousness (altered state of mind)
Blood glucose increased
Cardiac disorder
Central nervous system lesion (an abnormality in tissue of brain or spinal cord)
Coronary artery bypass
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetic coma
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Drug ineffective

What are the common drug interactions of Naltrexone Hydrochloride and Simvastatin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Blood glucose increased
Cardiac disorder
Coronary artery bypass
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetic coma
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Neuropathy peripheral (surface nerve damage)
Organic erectile dysfunction (inability to achieve or maintain an erection long enough to engage in sexual intercourse)
Pancreatitis (inflammation of pancreas)
Type 2 diabetes mellitus

50-59:

Sensitivity of teeth
Sinusitis (inflammation of sinus)
Spinal osteoarthritis (joint cartilage loss in spine)
Splenic lesion (lesion on spleen)
Spondylolisthesis (displacement of a vertebra or the vertebral column in relation to the vertebrae below)
Spondylolysis (a defect of a vertebra)
Synovial cyst (cyst of joint filled with synovial fluid)
Tinnitus (a ringing in the ears)
Tongue discolouration (colour change of tongue)
Vaginal discharge

60+:

Breast cancer female
Hepatocellular injury (liver injury)
Tremor (trembling or shaking movements in one or more parts of your body)
Abdominal discomfort
Blood alcohol increased
Central nervous system lesion (an abnormality in tissue of brain or spinal cord)
Drug ineffective
Dyspepsia (indigestion)
Flushing (the warm, red condition of human skin)
Hot flush (sudden feelings of heat)

What are the existing conditions these people have? *

Metastases To Bone (cancer spreads to bone): 7 people, 29.17%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 5 people, 20.83%
High Blood Pressure: 4 people, 16.67%
Suicidal Ideation: 3 people, 12.50%
Immunodeficiency Common Variable: 2 people, 8.33%
Gait Disturbance: 2 people, 8.33%

* Approximation only. Some reports may have incomplete information.

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