Naltrexone and Ritalin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Naltrexone (naltrexone) and Ritalin (methylphenidate hydrochloride). Common drug interactions include hypoaesthesia among females and sexual dysfunction among males.

The phase IV clinical study analyzes what interactions people have when they take Naltrexone and Ritalin. It is created by eHealthMe based on reports of 86 people who take the same drugs from the FDA, and is updated regularly.

What is Naltrexone?

Naltrexone has active ingredients of naltrexone. eHealthMe is studying from 4,835 Naltrexone users. Check the latest studies of Naltrexone.

What is Ritalin?

Ritalin has active ingredients of methylphenidate hydrochloride. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 29,427 Ritalin users. Check the latest studies of Ritalin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

86 people who take Naltrexone and Ritalin together, and have interactions are studied.

Naltrexone and Ritalin drug interactions.

What are the common drug interactions of Naltrexone and Ritalin, by gender? *:

female:

Hypoaesthesia (reduced sense of touch or sensation)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Panic disorder
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Peripheral swelling
Respiratory syncytial virus infection (viral disease of respiratory system)
Sensitivity of teeth
Sjogren's syndrome (a disease that causes dryness in the mouth and eyes)
Stress
Tooth extraction

male:

Sexual dysfunction (difficulty experienced by an individual or a couple during any stage of a normal sexual activity)
Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;)
Surgery
Weight increased
Appendicitis (inflammation of the appendix)
Apnoea (suspension of external breathing)
Bipolar disorder (mood disorder)
Blood pressure increased
Cardiac disorder
Cartilage injury

What are the common drug interactions of Naltrexone and Ritalin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Anxiety
Infertility male
Pain
Pyrexia (fever)
Suicidal ideation

30-39:

Fluid retention (an abnormal accumulation of fluid in the blood)
Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop)
Diarrhoea
Drug hypersensitivity
Nausea (feeling of having an urge to vomit)
Cardiac failure
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Respiratory syncytial virus infection (viral disease of respiratory system)
Vomiting
Hypersensitivity

40-49:

Fatigue (feeling of tiredness)
Sinusitis (inflammation of sinus)
Gastric bypass
Infusion site discomfort
Infusion site induration
Infusion site swelling
Urinary tract infection
Acne (skin problems that cause pimples)
Alcoholism (problems with alcohol)
Anxiety

50-59:

Peripheral swelling
Sensitivity of teeth
Sjogren's syndrome (a disease that causes dryness in the mouth and eyes)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)
Autonomic nervous system imbalance (autonomic nervous system is of net equal emphasis)
Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Compulsive shopping
Confusional state

60+:

Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Abdominal pain
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Carbon dioxide increased
Chest pain
Chronic kidney disease
Chronic sinusitis (long lasting inflammation of the paranasal sinuses)
Cough
Cystitis (inflammation of the wall of the bladder)
Diabetes mellitus inadequate control

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 56 people, 65.12%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 41 people, 47.67%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 10 people, 11.63%
Immunodeficiency Common Variable: 8 people, 9.30%
Hypogammaglobulinaemia (an abnormally low concentration of gamma globulin in the blood and increased risk of infection): 6 people, 6.98%
Chronic Inflammatory Demyelinating Polyradiculoneuropathy (long lasting infection of nerves outside brain and spinal cord): 5 people, 5.81%

* Approximation only. Some reports may have incomplete information.

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