Naprelan and Zantac drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Naprelan (naproxen sodium) and Zantac (ranitidine hydrochloride). Common drug interactions include hepatic steatosis among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Naprelan and Zantac. It is created by eHealthMe based on reports of 22 people who take the same drugs from the FDA, and is updated regularly.

What is Naprelan?

Naprelan has active ingredients of naproxen sodium. eHealthMe is studying from 731 Naprelan users. Check the latest studies of Naprelan.

What is Zantac?

Zantac has active ingredients of ranitidine hydrochloride. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 434,161 Zantac users. Check the latest studies of Zantac.

On Jul, 07, 2026

22 people who take Naprelan and Zantac together, and have interactions are studied.

What are the common drug interactions of Naprelan and Zantac, by gender? *:

female:

Hepatic steatosis (fatty liver disease)
Hip fracture
Interstitial lung disease
Intervertebral disc degeneration (spinal disc degeneration)
Intervertebral disc protrusion (spinal disc protrusion)
Joint range of motion decreased (disease of joint movement)
Lymphadenopathy (disease or enlargement of lymph nodes)
Metastases to bone (cancer spreads to bone)
Neck pain
Osteitis (a general term for inflammation of bone)

male:

Chronic kidney disease
Pain
Anxiety
Arteriosclerosis (thickening and hardening of arteries)
Arthralgia (joint pain)
Ataxia (loss of full control of bodily movements)
Atelectasis (partial or complete collapse of the lung)
Back pain
Balanitis candida (inflammation of the glands penis by infection with candida albicans)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)

What are the common drug interactions of Naprelan and Zantac, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Abdominal pain upper
Cholecystitis chronic (long lasting infection of gallbladder)
Decreased appetite
Diarrhoea
Nausea (feeling of having an urge to vomit)
Ovarian cyst (fluid filled sac of the ovary)
Swelling
Weight decreased

20-29:

Cholecystitis chronic (long lasting infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Pain

30-39:

n/a

40-49:

Gait disturbance
Hepatic steatosis (fatty liver disease)
Hip fracture
Interstitial lung disease
Intervertebral disc degeneration (spinal disc degeneration)
Intervertebral disc protrusion (spinal disc protrusion)
Joint range of motion decreased (disease of joint movement)
Lymphadenopathy (disease or enlargement of lymph nodes)
Metastases to bone (cancer spreads to bone)
Neck pain

50-59:

Insomnia (sleeplessness)
Spinal column stenosis (narrowing of spinal column)
Tooth disorder (tooth disease)
Abdominal discomfort
Actinomyces test positive
Anaphylactic reaction (serious allergic reaction)
Anxiety
Arteriosclerosis (thickening and hardening of arteries)
Arthralgia (joint pain)
Ataxia (loss of full control of bodily movements)

60+:

Chronic kidney disease
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Hyperchlorhydria (gastric acid levels are higher in stomach)
Pulmonary embolism (blockage of the main artery of the lung)
Rebound effect (take-back effect)
Renal failure (kidney dysfunction)
Renal haemangioma (kidney tumour filled with blood)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)

What are the existing conditions these people have? *

Arthritis (form of joint disorder that involves inflammation of one or more joints): 10 people, 45.45%
Metastases To Bone (cancer spreads to bone): 8 people, 36.36%
Pain: 4 people, 18.18%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 13.64%
Drowsiness: 3 people, 13.64%
Hypersensitivity: 2 people, 9.09%
High Blood Pressure: 2 people, 9.09%
Gout (uric acid crystals building up in the body): 2 people, 9.09%

* Approximation only. Some reports may have incomplete information.

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