Naprosyn and Xgeva drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Naprosyn (naproxen) and Xgeva (denosumab). Common drug interactions include cardiomegaly among females and constipation among males.

The phase IV clinical study analyzes what interactions people have when they take Naprosyn and Xgeva. It is created by eHealthMe based on reports of 27 people who take the same drugs from the FDA, and is updated regularly.

What is Naprosyn?

Naprosyn has active ingredients of naproxen. It is often used in pain. eHealthMe is studying from 16,738 Naprosyn users. Check the latest studies of Naprosyn.

What is Xgeva?

Xgeva has active ingredients of denosumab. It is often used in breast cancer. eHealthMe is studying from 37,717 Xgeva users. Check the latest studies of Xgeva.

On Aug, 10, 2026

27 people who take Naprosyn and Xgeva together, and have interactions are studied.

What are the common drug interactions of Naprosyn and Xgeva, by gender? *:

female:

Cardiomegaly (increased size of heart than normal)
Disseminated intravascular coagulation (systemic activation of blood coagulation)
Diverticulum intestinal (a pouch that is attached to the first part of the small intestine)
Emotional distress
Gingival bleeding (bleeding gums)
Gingival erosion (gum ulcer)
Gout (uric acid crystals building up in the body)
Haemolytic anaemia (anaemia due to haemolysis)
Impaired healing
Intervertebral disc protrusion (spinal disc protrusion)

male:

Constipation
Diarrhoea
Fatigue (feeling of tiredness)
Infection
Lung infection
Neuropathy peripheral (surface nerve damage)
Wound
Cancer pain
Hypocalcaemia (levels of calcium in blood serum are abnormally low)
Pelvic pain

What are the common drug interactions of Naprosyn and Xgeva, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Intervertebral disc protrusion (spinal disc protrusion)

40-49:

Acute hepatic failure
Disseminated intravascular coagulation (systemic activation of blood coagulation)
Haemolytic anaemia (anaemia due to haemolysis)
Thrombocytopenia (decrease of platelets in blood)
Hepatitis acute
Hepatitis (inflammation of the liver)

50-59:

Headache (pain in head)
Hepatitis a
Infection
Malaise (a feeling of general discomfort or uneasiness)
Nausea (feeling of having an urge to vomit)
Pain in jaw
Pyrexia (fever)
Transaminases increased
Blood bilirubin increased
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)

60+:

Neuropathy peripheral (surface nerve damage)
Constipation
Bone loss
Diverticulum intestinal (a pouch that is attached to the first part of the small intestine)
Dizziness
Fatigue (feeling of tiredness)
Gingival bleeding (bleeding gums)
Gingival erosion (gum ulcer)
Gout (uric acid crystals building up in the body)
Hepatic steatosis (fatty liver disease)

What are the existing conditions these people have? *

Metastases To Bone (cancer spreads to bone): 6 people, 22.22%
Multiple Myeloma (cancer of the plasma cells): 4 people, 14.81%
Neuropathy Peripheral (surface nerve damage): 3 people, 11.11%
Migraine (headache): 3 people, 11.11%
Insomnia (sleeplessness): 3 people, 11.11%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 3 people, 11.11%
Renal Cell Carcinoma (a kidney cancer): 2 people, 7.41%
Breast Cancer Metastatic: 2 people, 7.41%
Anaemia (lack of blood): 2 people, 7.41%

* Approximation only. Some reports may have incomplete information.

Do you take Naprosyn and Xgeva?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously