Naproxen and Estrogel drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Naproxen (naproxen) and Estrogel (estradiol). Common drug interactions include bronchitis among females.

The phase IV clinical study analyzes what interactions people have when they take Naproxen and Estrogel. It is created by eHealthMe based on reports of 42 people who take the same drugs from the FDA, and is updated regularly.

What is Naproxen?

Naproxen has active ingredients of naproxen. It is often used in pain. eHealthMe is studying from 72,032 Naproxen users. Check the latest studies of Naproxen.

What is Estrogel?

Estrogel has active ingredients of estradiol. It is often used in menopause. eHealthMe is studying from 2,921 Estrogel users. Check the latest studies of Estrogel.

On Jul, 13, 2026

42 people who take Naproxen and Estrogel together, and have interactions are studied.

Naproxen and Estrogel drug interactions.

What are the common drug interactions of Naproxen and Estrogel, by gender? *:

female:

Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Arthralgia (joint pain)
Diarrhoea
Nasopharyngitis (inflammation of the nasopharynx)
Neck pain
Pain in extremity
Peripheral swelling
Rhinorrhoea (watery mucus discharge from the nose)
Ankylosing spondylitis (type of arthritis affecting the spine)
Aphonia (inability to produce voice)

male:

n/a

What are the common drug interactions of Naproxen and Estrogel, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Dizziness
Feeling hot
Malaise (a feeling of general discomfort or uneasiness)
Blood cholesterol increased
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Pain in extremity
Peripheral swelling
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Tenderness (pain or discomfort when an affected area is touched)

50-59:

Dysstasia (difficulty in standing)
Gastroenteritis (inflammation of stomach and intestine)
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Hyperthermia (body temperature greatly above normal)
Influenza
Laryngitis (inflammation of the larynx)
Limb discomfort (discomfort in leg)
Lung disorder (lung disease)
Mobility decreased (ability to move is reduced)

60+:

Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)
Chronic kidney disease
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
White blood cell count decreased
Nikolsky's sign
Rash erythematous (redness of the skin)
Abdominal discomfort
Anaemia (lack of blood)
Ankle deformity
Arthralgia (joint pain)

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 13 people, 30.95%
Ankylosing Spondylitis (type of arthritis affecting the spine): 8 people, 19.05%

* Approximation only. Some reports may have incomplete information.

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