Naproxen and Methadose drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Naproxen (naproxen) and Methadose (methadone hydrochloride). Common drug interactions include depressed level of consciousness among females and completed suicide among males.

The phase IV clinical study analyzes what interactions people have when they take Naproxen and Methadose. It is created by eHealthMe based on reports of 41 people who take the same drugs from the FDA, and is updated regularly.

What is Naproxen?

Naproxen has active ingredients of naproxen. It is often used in pain. eHealthMe is studying from 72,033 Naproxen users. Check the latest studies of Naproxen.

What is Methadose?

Methadose has active ingredients of methadone hydrochloride. It is often used in pain. eHealthMe is studying from 5,101 Methadose users. Check the latest studies of Methadose.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 23, 2026

41 people who take Naproxen and Methadose together, and have interactions are studied.

Naproxen and Methadose drug interactions.

What are the common drug interactions of Naproxen and Methadose, by gender? *:

female:

Depressed level of consciousness
Mania (a state of abnormally elevated or irritable mood)
Respiratory depression (respiration has a rate below 12 breaths)
Fatigue (feeling of tiredness)
Nausea (feeling of having an urge to vomit)
Pleural effusion (water on the lungs)
Vomiting
Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)
Alopecia (absence of hair from areas of the body)
Breast cancer recurrent

male:

Completed suicide (act of taking one's own life)
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Death
Intentional self-injury
Sudden cardiac death
Withdrawal arrhythmia (irregular heart rate due to withdrawal of alcohol etc)

What are the common drug interactions of Naproxen and Methadose, by age (0-1 to 60+)? *:

0-1:

Pulmonary embolism (blockage of the main artery of the lung)
Drug withdrawal syndrome neonatal (prenatal nas is caused by discontinuation of drugs taken by the pregnant mother)
Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)

2-9:

n/a

10-19:

Weight increased
Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Thrombocytopenic purpura (a bleeding disorder in which the immune system destroys platelets)

20-29:

Maternal exposure during pregnancy (use of substance during pregnancy)
Papillary thyroid cancer
Premature delivery
Completed suicide (act of taking one's own life)
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Death

30-39:

Completed suicide (act of taking one's own life)
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Sudden cardiac death
Withdrawal arrhythmia (irregular heart rate due to withdrawal of alcohol etc)

40-49:

Drug ineffective
Drug intolerance (drug sensitivity)
Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)
Depressed level of consciousness
Mania (a state of abnormally elevated or irritable mood)
Respiratory depression (respiration has a rate below 12 breaths)
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Abdominal pain
Anxiety
Blood glucose increased

50-59:

Alopecia (absence of hair from areas of the body)
Hepatic steatosis (fatty liver disease)
Hepatitis c
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Hypoaesthesia (reduced sense of touch or sensation)
Hypokalaemia (low potassium)
Injury
Intervertebral disc degeneration (spinal disc degeneration)
Intervertebral disc protrusion (spinal disc protrusion)
Intervertebral disc space narrowing (spinal disc space narrowing)

60+:

Completed suicide (act of taking one's own life)

What are the existing conditions these people have? *

Complex Regional Pain Syndrome (long lasting pain condition most often affecting one of the limbs (arms, legs, hands, or feet)): 19 people, 46.34%
Neuralgia (pain in one or more nerves): 4 people, 9.76%
Stress And Anxiety: 3 people, 7.32%
Resorption Bone Increased: 3 people, 7.32%
High Blood Pressure: 3 people, 7.32%

* Approximation only. Some reports may have incomplete information.

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