Naproxen and Optivar drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Naproxen (naproxen) and Optivar (azelastine hydrochloride). Common drug interactions include haematochezia among females and asthma among males.

The phase IV clinical study analyzes what interactions people have when they take Naproxen and Optivar. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Naproxen?

Naproxen has active ingredients of naproxen. It is often used in pain. eHealthMe is studying from 72,034 Naproxen users. Check the latest studies of Naproxen.

What is Optivar?

Optivar has active ingredients of azelastine hydrochloride. eHealthMe is studying from 367 Optivar users. Check the latest studies of Optivar.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

12 people who take Naproxen and Optivar together, and have interactions are studied.

What are the common drug interactions of Naproxen and Optivar, by gender? *:

female:

Haematochezia (passage of stools containing blood)
Increased tendency to bruise (increased tendency to injure the underlying soft tissue or bone)
Injection site pain
Leukopenia (less number of white blood cells in blood)
Aortic arteriosclerosis (hardening of the aortic arteries)
Aortic calcification (aortic calcification sign of heart valve disease)
Aphasia (damage to the parts of the brain that control language)
Blood pressure increased
Blood prolactin increased
Cerebellar atrophy (degeneration of the section of the brain responsible for balance, voluntary muscle movements)

male:

Asthma
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Headache (pain in head)
Hypersensitivity
Hypertension (high blood pressure)
Nausea (feeling of having an urge to vomit)
Polyp
Rash
Type 2 diabetes mellitus

What are the common drug interactions of Naproxen and Optivar, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Aphasia (damage to the parts of the brain that control language)
Complex partial seizures (epileptic seizure)
Confusional state
Deja vu (the experience of thinking that a new situation had occurred before)
Depression
Dissociation
Dysphonia (speech disorder attributable to a disorder of phonation)
Fatigue (feeling of tiredness)
Feeling hot
Flushing (the warm, red condition of human skin)

30-39:

n/a

40-49:

Blood pressure increased
Heart rate increased
Tachycardia (a heart rate that exceeds the range of 100 beats/min)

50-59:

Asthma
Deafness
Haematochezia (passage of stools containing blood)
Headache (pain in head)
Hypertension (high blood pressure)
Increased tendency to bruise (increased tendency to injure the underlying soft tissue or bone)
Leukopenia (less number of white blood cells in blood)
Nausea (feeling of having an urge to vomit)

60+:

Aortic arteriosclerosis (hardening of the aortic arteries)
Aortic calcification (aortic calcification sign of heart valve disease)
Small cell lung cancer (small cell cancer tumour of lung)
Type 2 diabetes mellitus
Cerebellar atrophy (degeneration of the section of the brain responsible for balance, voluntary muscle movements)
Cerebral atrophy (decrement in size of brain)
Cerebral ischaemia (insufficient blood flow to the brain to meet metabolic demand)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Pericardial effusion (fluid around the heart)
Pneumonia

What are the existing conditions these people have? *

Asthma: 5 people, 41.67%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 2 people, 16.67%
Type 2 Diabetes: 1 person, 8.33%
High Blood Cholesterol: 1 person, 8.33%
Birth Control: 1 person, 8.33%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 1 person, 8.33%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 1 person, 8.33%
Depression: 1 person, 8.33%
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it): 1 person, 8.33%
Infection: 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

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