Naproxen and Tessalon drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Naproxen (naproxen) and Tessalon (benzonatate). Common drug interactions include vomiting among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Naproxen and Tessalon. It is created by eHealthMe based on reports of 90 people who take the same drugs from the FDA, and is updated regularly.

What is Naproxen?

Naproxen has active ingredients of naproxen. It is often used in pain. eHealthMe is studying from 72,033 Naproxen users. Check the latest studies of Naproxen.

What is Tessalon?

Tessalon has active ingredients of benzonatate. It is often used in cough. eHealthMe is studying from 6,493 Tessalon users. Check the latest studies of Tessalon.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 23, 2026

90 people who take Naproxen and Tessalon together, and have interactions are studied.

Naproxen and Tessalon drug interactions.

What are the common drug interactions of Naproxen and Tessalon, by gender? *:

female:

Vomiting
Chronic kidney disease
Asthma
Contusion (a type of hematoma of tissue in which capillaries)
Decreased appetite
Dry mouth
Emotional distress
Foot fracture
Heart rate increased
Pneumonia

male:

Chronic kidney disease
Osteonecrosis (death of bone)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Balance disorder
Emotional distress
Haematuria (presence of blood in urine)
Renal failure (kidney dysfunction)
Renal injury (kidney injury)
Vision blurred
Abdominal pain upper

What are the common drug interactions of Naproxen and Tessalon, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Erythema (redness of the skin)
Pruritus (severe itching of the skin)
Throat irritation
Vision blurred

20-29:

Abdominal pain
Anaemia (lack of blood)
Cardiac disorder
Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
Constipation
Diarrhoea
Electrocardiogram qt prolonged
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Iron deficiency
Malaise (a feeling of general discomfort or uneasiness)

30-39:

Hypertension (high blood pressure)
Dizziness
Heart rate increased
Constipation
Decreased appetite
Pulmonary embolism (blockage of the main artery of the lung)
Restless legs syndrome (a powerful urge to move your legs)
Stress
Vertigo
Asthma

40-49:

Chronic kidney disease
Anxiety
Foot fracture
Emotional distress
Osteonecrosis (death of bone)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Bone density decreased
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Blood creatinine increased
Fall

50-59:

Blood cholesterol increased
Blood creatine decreased
Blood urea increased
Bone pain
Cardiac flutter (abnormal heart rhythm)
Ceruloplasmin decreased
Confusional state
Contusion (a type of hematoma of tissue in which capillaries)
Crying
Deformity (disfigurement)

60+:

Chronic kidney disease
Fatigue (feeling of tiredness)
Dysphonia (speech disorder attributable to a disorder of phonation)
Dyspnoea (difficult or laboured respiration)
Fall
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Muscular weakness (muscle weakness)
Pericardial effusion (fluid around the heart)
Plasma cell myeloma (cancer that begins in plasma cells)
Pneumonitis (inflammation of the walls of the alveoli in the lungs)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 13 people, 14.44%
Stress And Anxiety: 10 people, 11.11%
High Blood Pressure: 10 people, 11.11%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 7.78%
Nausea (feeling of having an urge to vomit): 5 people, 5.56%
Depression: 5 people, 5.56%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 5 people, 5.56%

* Approximation only. Some reports may have incomplete information.

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