Naproxen and Tobradex drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Naproxen (naproxen) and Tobradex (dexamethasone; tobramycin). Common drug interactions include joint swelling among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Naproxen and Tobradex. It is created by eHealthMe based on reports of 50 people who take the same drugs from the FDA, and is updated regularly.

What is Naproxen?

Naproxen has active ingredients of naproxen. It is often used in pain. eHealthMe is studying from 72,034 Naproxen users. Check the latest studies of Naproxen.

What is Tobradex?

Tobradex has active ingredients of dexamethasone; tobramycin. It is often used in eye infection. eHealthMe is studying from 3,154 Tobradex users. Check the latest studies of Tobradex.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

50 people who take Naproxen and Tobradex together, and have interactions are studied.

Naproxen and Tobradex drug interactions.

What are the common drug interactions of Naproxen and Tobradex, by gender? *:

female:

Joint swelling
Muscular weakness (muscle weakness)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Neutropenia (an abnormally low number of neutrophils)
Oropharyngeal pain
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve)
Scoliosis (a medical condition in which a person's spine is curved from side to side)
Skin reaction
Stress

male:

Chronic kidney disease
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Balance disorder
Bone density decreased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Corneal thinning
Corneal ulcer
Cough
Depression
Emotional distress

What are the common drug interactions of Naproxen and Tobradex, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Cholecystitis (infection of gallbladder)
Gallbladder disorder
Injury
Pancreatitis (inflammation of pancreas)

20-29:

Cardiac failure
Drug intolerance (drug sensitivity)
Dysphagia (a condition in which swallowing is difficult or painful)
Vomiting

30-39:

n/a

40-49:

Cellulitis (infection under the skin)
Dyschezia (difficulty in defecating)
Eye swelling
Generalised oedema (swelling all over the body)
Ill-defined disorder
Infusion site extravasation (flow of (blood or lymph) from infusion site)
Injection site pain
Injection site swelling
Ocular hyperaemia (an abnormally large amount of blood in eye)
Rash

50-59:

Dry skin
Joint swelling
Psoriasis (immune-mediated disease that affects the skin)
Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop)
Skin reaction
Anaemia (lack of blood)
Cytomegalovirus hepatitis (virus infection of liver)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Nephrogenic anaemia (anaemia due to kidney disease)

60+:

Conjunctival bleb (blister of eye covering)
Conjunctival erosion (removal of conjunctiva)
Abdominal mass (localized enlargement or swelling in the human abdomen)
Affect lability (emotional incontinence)
Anaemia (lack of blood)
Anaemia postoperative
Ankle fracture
Anosognosia (ignorance of the presence of disease)
Anxiety
Aortic arteriosclerosis (hardening of the aortic arteries)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 11 people, 22.00%
High Blood Pressure: 10 people, 20.00%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 7 people, 14.00%
High Blood Cholesterol: 7 people, 14.00%
Dry Eyes (lack of adequate tears): 6 people, 12.00%
Lacrimation Increased: 5 people, 10.00%
Diabetic Retinal Oedema (excessive build-up of fluid in the retina due to diabetes): 5 people, 10.00%
Fungal Nail Infection: 5 people, 10.00%
Vitamin B12 Deficiency: 5 people, 10.00%
Vulvovaginal Discomfort: 5 people, 10.00%

* Approximation only. Some reports may have incomplete information.

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