Naproxen and Tofranil drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Naproxen (naproxen) and Tofranil (imipramine hydrochloride). Common drug interactions include pain in extremity among females and bipolar disorder among males.

The phase IV clinical study analyzes what interactions people have when they take Naproxen and Tofranil. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Naproxen?

Naproxen has active ingredients of naproxen. It is often used in pain. eHealthMe is studying from 72,033 Naproxen users. Check the latest studies of Naproxen.

What is Tofranil?

Tofranil has active ingredients of imipramine hydrochloride. It is often used in depression. eHealthMe is studying from 2,012 Tofranil users. Check the latest studies of Tofranil.

On Aug, 10, 2026

14 people who take Naproxen and Tofranil together, and have interactions are studied.

Naproxen and Tofranil drug interactions.

What are the common drug interactions of Naproxen and Tofranil, by gender? *:

female:

Pain in extremity
Anaemia (lack of blood)
Blood triglycerides increased
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Cataract (clouding of the lens inside the eye)
Epistaxis (bleed from the nose)
Feeling hot
Headache (pain in head)
Hypertension (high blood pressure)
Nasopharyngitis (inflammation of the nasopharynx)

male:

Bipolar disorder (mood disorder)
Chest discomfort
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Confusional state
Dyspepsia (indigestion)
Fatigue (feeling of tiredness)
Somnolence (a state of near-sleep, a strong desire for sleep)
Urinary tract obstruction

What are the common drug interactions of Naproxen and Tofranil, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Cardiac arrest
Completed suicide (act of taking one's own life)
Respiratory arrest (cessation of normal respiration due to failure of the lungs to function effectively)

20-29:

n/a

30-39:

Completed suicide (act of taking one's own life)
Multiple drug overdose intentional

40-49:

Drug dependence
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)

50-59:

Bipolar disorder (mood disorder)
Chest discomfort
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Confusional state
Dyspepsia (indigestion)
Fatigue (feeling of tiredness)
Somnolence (a state of near-sleep, a strong desire for sleep)
Urinary tract obstruction

60+:

Blood cholesterol increased
Drug ineffective
Hypertension (high blood pressure)
Nasopharyngitis (inflammation of the nasopharynx)
Procedural pain
Renal colic (renal pain)
Sinusitis (inflammation of sinus)
Skin discolouration (change of skin colour)
Somnolence (a state of near-sleep, a strong desire for sleep)
Tendonitis (a condition that causes pain and swelling of tendons)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 35.71%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 28.57%
Tendon Disorder (disease of tendon): 3 people, 21.43%
Quit Smoking: 3 people, 21.43%
Osteopenia (a condition where bone mineral density is lower than normal): 3 people, 21.43%
High Blood Cholesterol: 3 people, 21.43%
Bipolar Ii Disorder (characterized by at least one episode of hypomania and at least one episode of major depression): 3 people, 21.43%
Lung Adenocarcinoma (a form of non-small cell lung cancer): 1 person, 7.14%
Breakthrough Pain: 1 person, 7.14%
Back Pain: 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

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