Naproxen and Zicam drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Naproxen (naproxen) and Zicam (zinc gluconate). Common drug interactions include arthropathy among females and abdominal discomfort among males.

The phase IV clinical study analyzes what interactions people have when they take Naproxen and Zicam. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Naproxen?

Naproxen has active ingredients of naproxen. It is often used in pain. eHealthMe is studying from 72,033 Naproxen users. Check the latest studies of Naproxen.

What is Zicam?

Zicam has active ingredients of zinc gluconate. It is often used in herpes labialis (oral herpes simplex). eHealthMe is studying from 5,298 Zicam users. Check the latest studies of Zicam.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 22, 2026

20 people who take Naproxen and Zicam together, and have interactions are studied.

What are the common drug interactions of Naproxen and Zicam, by gender? *:

female:

Arthropathy
Hand fracture
Herpes zoster
Joint dislocation (a joint position is changed from normal position)
Malaise (a feeling of general discomfort or uneasiness)
Multiple allergies (allergy to multiple agents)
Rotator cuff syndrome (a spectrum of conditions affecting the rotator cuff tendons of the shoulder)
Accident
Disability
Scoliosis (a medical condition in which a person's spine is curved from side to side)

male:

Abdominal discomfort
Arthralgia (joint pain)
Erectile dysfunction
Feelings of worthlessness
Hemiplegia (paralysis of one side of the body)
Hypoaesthesia (reduced sense of touch or sensation)
Hypokinesia (decreased bodily movement)
Intervertebral disc injury (spinal disc injury)
Ischaemic stroke (stroke; caused by an interruption in the flow of blood to the brain)
Memory impairment

What are the common drug interactions of Naproxen and Zicam, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Activities of daily living impaired
Anaemia (lack of blood)
Anxiety
Dizziness
Dyspnoea (difficult or laboured respiration)
Emotional distress
Fatigue (feeling of tiredness)
Gallbladder disorder
General physical health deterioration (weak health status)
High risk pregnancy

30-39:

n/a

40-49:

Uterine prolapse
Ageusia (loss of taste functions of the tongue)

50-59:

Abdominal discomfort
Arthralgia (joint pain)
Asthenia (weakness)
Bone density decreased
Bone disorder
Bone pain
Cardiac arrest
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Deformity (disfigurement)
Disturbance in attention

60+:

Arthropathy
Hand fracture
Sinusitis (inflammation of sinus)
Gait disturbance
Ankle fracture
Back injury
Blood cholesterol increased
Fall
Hypertension (high blood pressure)
Osteopenia (a condition where bone mineral density is lower than normal)

What are the existing conditions these people have? *

Stress And Anxiety: 12 people, 60.00%
Depression: 12 people, 60.00%
Back Pain: 9 people, 45.00%
Gastric Ulcer (stomach ulcer): 9 people, 45.00%
Joint Pain: 9 people, 45.00%
Gastritis (inflammation of stomach): 9 people, 45.00%
Sleep Disorder: 9 people, 45.00%
Cardiac Disorder: 9 people, 45.00%
Neck Pain: 8 people, 40.00%
High Blood Cholesterol: 8 people, 40.00%

* Approximation only. Some reports may have incomplete information.

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