Narcan and Pyridium drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Narcan (naloxone hydrochloride) and Pyridium (phenazopyridine hydrochloride). Common drug interactions include infusion related reaction among females and pelvic infection among males.

The phase IV clinical study analyzes what interactions people have when they take Narcan and Pyridium. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Narcan?

Narcan has active ingredients of naloxone hydrochloride. eHealthMe is studying from 3,687 Narcan users. Check the latest studies of Narcan.

What is Pyridium?

Pyridium has active ingredients of phenazopyridine hydrochloride. It is often used in urinary tract infection. eHealthMe is studying from 1,841 Pyridium users. Check the latest studies of Pyridium.

On Jul, 13, 2026

13 people who take Narcan and Pyridium together, and have interactions are studied.

What are the common drug interactions of Narcan and Pyridium, by gender? *:

female:

Infusion related reaction
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Blood pressure increased
Constipation
Hypoxia (low oxygen in tissues)
Libido decreased (loss of interest in sex)
Nausea (feeling of having an urge to vomit)
Rash

male:

Pelvic infection
Chronic kidney disease
Pelvic pain
Renal failure (kidney dysfunction)

What are the common drug interactions of Narcan and Pyridium, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Chronic kidney disease
Dyspepsia (indigestion)
Gastritis (inflammation of stomach)
Renal failure (kidney dysfunction)

40-49:

n/a

50-59:

Hypoxia (low oxygen in tissues)
Central pain syndrome (neurological condition caused by damage or malfunction in the central nervous system)
Abdominal pain
Chronic kidney disease
Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Infusion related reaction
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)

60+:

Pelvic infection
Pelvic pain

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 46.15%
Infection: 5 people, 38.46%
Pain: 5 people, 38.46%
Indigestion: 5 people, 38.46%
Constipation: 3 people, 23.08%
Flatulence (flatus expelled through the anus): 3 people, 23.08%
Renal Disorder (kidney disease): 2 people, 15.38%
Asthma: 2 people, 15.38%
Blood Pressure Abnormal: 2 people, 15.38%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 2 people, 15.38%

* Approximation only. Some reports may have incomplete information.

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