Neurontin and Orphenadrine citrate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Neurontin (gabapentin) and Orphenadrine citrate (orphenadrine citrate). Common drug interactions include gastrooesophageal reflux disease among females and abdominal discomfort among males.

The phase IV clinical study analyzes what interactions people have when they take Neurontin and Orphenadrine citrate. It is created by eHealthMe based on reports of 37 people who take the same drugs from the FDA, and is updated regularly.

What is Neurontin?

Neurontin has active ingredients of gabapentin. It is often used in neuralgia. eHealthMe is studying from 107,468 Neurontin users. Check the latest studies of Neurontin.

What is Orphenadrine citrate?

Orphenadrine citrate has active ingredients of orphenadrine citrate. It is often used in muscle aches. eHealthMe is studying from 1,189 Orphenadrine citrate users. Check the latest studies of Orphenadrine citrate.

On Jul, 19, 2026

37 people who take Neurontin and Orphenadrine citrate together, and have interactions are studied.

Neurontin and Orphenadrine citrate drug interactions.

What are the common drug interactions of Neurontin and Orphenadrine Citrate, by gender? *:

female:

Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Mass
Obesity (having too much body fat)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Abdominal pain
Aggression
Atypical femur fracture
Anxiety
Arthralgia (joint pain)
Road traffic accident

male:

Abdominal discomfort
Abdominal distension
Muscular weakness (muscle weakness)
Tardive dyskinesia (a disorder that involves involuntary movements)
Tremor (trembling or shaking movements in one or more parts of your body)
Anxiety
Emotional disorder
Eructation (release of gas from the digestive tract)
Extrapyramidal disorder (involuntary muscle spasms in the face and neck)
Gastritis erosive (a break in the surface layer of the membrane lining the stomach with infection)

What are the common drug interactions of Neurontin and Orphenadrine Citrate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Anxiety
Emotional distress
Road traffic accident
Arthralgia (joint pain)
Cushingoid (obesity and weakening of the muscles)
Dehydration (dryness resulting from the removal of water)
Disorientation (disability in which the senses of time, direction, and recognition of people and places)
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Duodenal ulcer
Dyspnoea (difficult or laboured respiration)

40-49:

Activities of daily living impaired
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Dizziness
Dysaesthesia (abnormal sensation)
Gait disturbance
Hypoaesthesia (reduced sense of touch or sensation)
Leukopenia (less number of white blood cells in blood)
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Platelet count decreased

50-59:

Road traffic accident
Schizophrenia, paranoid type (delusions and auditory hallucinations but relatively normal intellectual functioning and expression of affect)
Suicide attempt
Diabetic nephropathy (diabetic kidney disease)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Mass
Muscular weakness (muscle weakness)
Obesity (having too much body fat)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Aggression

60+:

Muscular weakness (muscle weakness)
Abdominal pain upper
Bone pain
Breast cancer
Chest pain
Chorea (abnormal involuntary movement disorder)
Constipation
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Decreased activity
Depression

What are the existing conditions these people have? *

Pain: 10 people, 27.03%
Muscle Spasms (muscle contraction): 4 people, 10.81%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 8.11%
Insomnia (sleeplessness): 3 people, 8.11%
Ill-Defined Disorder: 3 people, 8.11%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 8.11%
Diabetic Neuropathy (neuropathic disorders that are associated with diabetes mellitus): 3 people, 8.11%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 2 people, 5.41%
Osteoporosis (bones weak and more likely to break): 2 people, 5.41%
Muscle Tightness: 2 people, 5.41%

* Approximation only. Some reports may have incomplete information.

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