Nexium and Precedex drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Nexium (esomeprazole magnesium) and Precedex (dexmedetomidine). Common drug interactions include cholelithiasis among females and acute respiratory failure among males.

The phase IV clinical study analyzes what interactions people have when they take Nexium and Precedex. It is created by eHealthMe based on reports of 37 people who take the same drugs from the FDA, and is updated regularly.

What is Nexium?

Nexium has active ingredients of esomeprazole magnesium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 245,677 Nexium users. Check the latest studies of Nexium.

What is Precedex?

Precedex has active ingredients of dexmedetomidine. eHealthMe is studying from 1,007 Precedex users. Check the latest studies of Precedex.

On Jul, 12, 2026

37 people who take Nexium and Precedex together, and have interactions are studied.

What are the common drug interactions of Nexium and Precedex, by gender? *:

female:

Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Chronic kidney disease
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Death
Depression
Disability
Duodenal perforation (complication of duodenal ulcer)
Dyspnoea exertional (breathlessness or shortness of breath)
Emotional distress

male:

Acute respiratory failure
Cardiac arrest
Escherichia test positive
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Lung transplant
Pneumonia
Rash
Respiratory depression (respiration has a rate below 12 breaths)
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
Supraventricular tachycardia (rapid heart rhythm originating at or above the atrioventricular node)

What are the common drug interactions of Nexium and Precedex, by age (0-1 to 60+)? *:

0-1:

Abdominal compartment syndrome (increased pressure in abdomen)
Ascites (accumulation of fluid in the abdominal cavity)
Blood lactic acid increased
Cholecystitis (infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Coagulopathy (blood's ability to clot is impaired)
Duodenal perforation (complication of duodenal ulcer)
Enterococcal infection
Fluid retention (an abnormal accumulation of fluid in the blood)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)

2-9:

n/a

10-19:

Coagulopathy (blood's ability to clot is impaired)
Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
Iron deficiency anaemia
Multi-organ failure (multisystem organ failure)
Neurological symptom (symptoms of nervous system disease)
Pancreatitis (inflammation of pancreas)
Pancreatitis necrotising (inflammation of the pancreas cause death of tissue in pancreas)
Respiratory failure (inadequate gas exchange by the respiratory system)
Syncope (loss of consciousness with an inability to maintain postural tone)

20-29:

Neuroleptic malignant syndrome (a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic agents)
Blood triglycerides increased

30-39:

Renal impairment (severely reduced kidney function)
Diarrhoea
Kaposi's sarcoma (a tumour caused by human herpes virus)
Organising pneumonia (pathologically by the presence in the distal air spaces of buds of granulation tissue)
Pseudomonas infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa)

40-49:

Eosinophilic pneumonia (eosinophil accumulates in the lung)
Abdominal pain
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Ataxia (loss of full control of bodily movements)
Bradycardia (abnormally slow heart action)
Cardiac arrest
Depression
Disability
Dysphagia (a condition in which swallowing is difficult or painful)

50-59:

Liver disorder (liver diseases)
Pancreatitis acute (sudden inflammation of pancreas)
Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin)
Anaphylactic reaction (serious allergic reaction)
Anxiety
Blood pressure decreased
Bradycardia (abnormally slow heart action)
Death
Drug screen positive
Electrocardiogram st segment depression

60+:

Acute respiratory failure
Circulatory collapse
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Lung transplant
Pain
Pneumonia
Rash
Respiratory depression (respiration has a rate below 12 breaths)
Supraventricular tachycardia (rapid heart rhythm originating at or above the atrioventricular node)
Cardiac failure

What are the existing conditions these people have? *

Sedation: 8 people, 21.62%
High Blood Pressure: 6 people, 16.22%
Pain: 5 people, 13.51%
Fever: 4 people, 10.81%
Hyperlipidaemia (presence of excess lipids in the blood): 4 people, 10.81%
Insomnia (sleeplessness): 4 people, 10.81%
Gastric Ulcer (stomach ulcer): 4 people, 10.81%
Cardiac Failure: 3 people, 8.11%
Constipation: 3 people, 8.11%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 3 people, 8.11%

* Approximation only. Some reports may have incomplete information.

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