Niacin and Rezulin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Niacin (niacin) and Rezulin (troglitazone). Common drug interactions include fatigue among females and blood alkaline phosphatase nos increased among males.

The phase IV clinical study analyzes what interactions people have when they take Niacin and Rezulin. It is created by eHealthMe based on reports of 36 people who take the same drugs from the FDA, and is updated regularly.

What is Niacin?

Niacin has active ingredients of niacin. It is often used in high blood cholesterol. eHealthMe is studying from 9,009 Niacin users. Check the latest studies of Niacin.

What is Rezulin?

Rezulin has active ingredients of troglitazone. eHealthMe is studying from 8,764 Rezulin users. Check the latest studies of Rezulin.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

36 people who take Niacin and Rezulin together, and have interactions are studied.

What are the common drug interactions of Niacin and Rezulin, by gender? *:

female:

Fatigue (feeling of tiredness)
Glaucoma (increased fluid pressure in the eye with vision loss)
Haematochezia (passage of stools containing blood)
Hepatitis (inflammation of the liver)
Nausea (feeling of having an urge to vomit)
Pruritus (severe itching of the skin)
Rhinitis (a medical term for irritation and inflammation of the mucous membrane inside the nose)
Tonsillitis (inflammation of tonsil)
Vomiting
Weight increased

male:

Blood alkaline phosphatase nos increased
Chest pain
Aspartate aminotransferase increased
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Blood albumin decreased
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Epistaxis (bleed from the nose)
Haematuria present (presence of blood in urine due to trauma)
Left ventricular failure (left ventricle fails to contract forcefully)
Oedema (fluid collection in tissue)

What are the common drug interactions of Niacin and Rezulin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Biliary cirrhosis primary (primary biliary cirrhosis (pbc) is a long-term liver disease that damages the small bile ducts in the liver. the build-up of bile damages the liver)
Chest pain
Cholangitis sclerosing (infection and obstruction of bile duct)
Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
Earache (ear pain)
Gastroenteritis helicobacter (inflammation of stomach and intestine caused by helicobacter infection)
Glycosylated haemoglobin increased
Inflammation
Lacrimation increased
Muscle cramps (painful sensations caused by muscle contraction)

40-49:

Abdominal pain
Angina pectoris (chest pain due to ischemia of the heart muscle)
Appetite decreased (decreased appetite occurs when you have a reduced desire to eat)
Chest pain
Haematuria present (presence of blood in urine due to trauma)
Left ventricular failure (left ventricle fails to contract forcefully)
Nausea (feeling of having an urge to vomit)
Oedema lower limb (fluid collection in tissue of lower leg)
Proteinuria present
Sweating increased (excess sweating)

50-59:

Foot deformity (functional disability of foot)
Functional gastrointestinal disorder (functional problem in separate organs of gastrointestinal system)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Jaundice cholestatic
Mass
Neuropathy peripheral (surface nerve damage)
Onychomycosis (fungal infection of the nail)
Renal impairment (severely reduced kidney function)
Upper respiratory tract infection
Venous insufficiency (poor circulation of blood caused by damaged or enlarged veins)

60+:

Blood alkaline phosphatase nos increased
Blood albumin decreased
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Oedema (fluid collection in tissue)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Snoring
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Blood lactate dehydrogenase increased
Bone marrow depression (decreased ability or inability of the bone marrow to produce blood cells)

What are the existing conditions these people have? *

Diabetes: 4 people, 11.11%
Weight Loss: 2 people, 5.56%
Ill-Defined Disorder: 2 people, 5.56%
Diabetic Neuropathy (neuropathic disorders that are associated with diabetes mellitus): 2 people, 5.56%
Diabetic Nephropathy (diabetic kidney disease): 2 people, 5.56%
Back Pain: 2 people, 5.56%

* Approximation only. Some reports may have incomplete information.

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