Nicotine and Perphenazine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Nicotine (nicotine) and Perphenazine (perphenazine). Common drug interactions include chronic kidney disease among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Nicotine and Perphenazine. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Nicotine?

Nicotine has active ingredients of nicotine. It is often used in quit smoking. eHealthMe is studying from 20,443 Nicotine users. Check the latest studies of Nicotine.

What is Perphenazine?

Perphenazine has active ingredients of perphenazine. It is often used in bipolar i disorder. eHealthMe is studying from 2,712 Perphenazine users. Check the latest studies of Perphenazine.

On Jul, 18, 2026

13 people who take Nicotine and Perphenazine together, and have interactions are studied.

Nicotine and Perphenazine drug interactions.

What are the common drug interactions of Nicotine and Perphenazine, by gender? *:

female:

Chronic kidney disease
Renal failure (kidney dysfunction)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Death
Intestinal resection
Suicidal ideation
Therapeutic response decreased (less preventive response)

male:

Chronic kidney disease
Neutropenia (an abnormally low number of neutrophils)
Hypoglycaemia (deficiency of glucose in the bloodstream)
Insomnia (sleeplessness)
Nicotine dependence
Obesity (having too much body fat)
Pancreatitis (inflammation of pancreas)
Psychomotor hyperactivity (feelings of extreme restlessness)
Weight decreased
Weight increased

What are the common drug interactions of Nicotine and Perphenazine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Agitation (state of anxiety or nervous excitement)
Drug dependence
Euphoric mood (excessively happy but may become angry or irritable)
Insomnia (sleeplessness)
Nicotine dependence
Pancreatitis (inflammation of pancreas)
Psychomotor hyperactivity (feelings of extreme restlessness)

20-29:

Neutropenia (an abnormally low number of neutrophils)

30-39:

Granulocytopenia (lack of granulocyte)

40-49:

Chronic kidney disease
Renal failure (kidney dysfunction)

50-59:

Obesity (having too much body fat)
Weight decreased
Weight increased
Blood cholesterol increased
Blood glucose increased
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Erectile dysfunction
Hypoglycaemia (deficiency of glucose in the bloodstream)

60+:

Application site irritation
Chronic kidney disease
Myalgia (muscle pain)
Overdose
Renal failure (kidney dysfunction)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 30.77%
High Blood Pressure: 3 people, 23.08%
Stress And Anxiety: 3 people, 23.08%
Depression: 3 people, 23.08%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 2 people, 15.38%
Schizoaffective Disorder (a mental disorder characterized by disordered thought): 2 people, 15.38%
Diabetes: 2 people, 15.38%
Prostatomegaly (enlargement of the prostate): 2 people, 15.38%
Pain: 2 people, 15.38%
Inflammation: 2 people, 15.38%

* Approximation only. Some reports may have incomplete information.

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