Nicotrol and Flexeril drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Nicotrol (nicotine) and Flexeril (cyclobenzaprine hydrochloride). Common drug interactions include withdrawal syndrome among females and ankle fracture among males.

The phase IV clinical study analyzes what interactions people have when they take Nicotrol and Flexeril. It is created by eHealthMe based on reports of 46 people who take the same drugs from the FDA, and is updated regularly.

What is Nicotrol?

Nicotrol has active ingredients of nicotine. eHealthMe is studying from 4,104 Nicotrol users. Check the latest studies of Nicotrol.

What is Flexeril?

Flexeril has active ingredients of cyclobenzaprine hydrochloride. It is often used in muscle spasms. eHealthMe is studying from 38,308 Flexeril users. Check the latest studies of Flexeril.

On Jul, 24, 2026

46 people who take Nicotrol and Flexeril together, and have interactions are studied.

Nicotrol and Flexeril drug interactions.

What are the common drug interactions of Nicotrol and Flexeril, by gender? *:

female:

Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)
Abnormal behaviour
Acute myocardial infarction (acute heart attack)
Application site bruising
Application site dermatitis
Application site erythema (redness of the skin at application site)
Application site pruritus (application site severe itching of the skin)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Blood creatinine increased
Bronchospasm (spasm of bronchial smooth muscle producing narrowing of the bronchi)

male:

Ankle fracture
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Fall
Lung neoplasm malignant (cancer tumour of lung)
Retching (strong involuntary effort to vomit)
Rhinorrhoea (watery mucus discharge from the nose)
Vertigo
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Arthralgia (joint pain)
Disability

What are the common drug interactions of Nicotrol and Flexeril, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Drug ineffective
Suicidal ideation

40-49:

Haematemesis (vomiting of blood)
Hypoaesthesia (reduced sense of touch or sensation)
Insomnia (sleeplessness)
Labyrinthitis (inflammation of the labyrinth or inner ear)
Oesophageal disorder (disease of oesophagus)
Vision blurred
Anxiety
Arthralgia (joint pain)
Drug ineffective
Impaired work ability

50-59:

Anxiety
Blood cholesterol increased
Depression
Headache (pain in head)
Hypertension (high blood pressure)
Asthma
Atherosclerosis (disorder of the arteries)
Carotid artery stenosis (narrowing of carotid artery)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Disturbance in attention

60+:

Agitation (state of anxiety or nervous excitement)
Tobacco withdrawal symptoms
Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)
Application site bruising
Application site dermatitis
Application site erythema (redness of the skin at application site)
Application site pruritus (application site severe itching of the skin)
Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs)
Fall
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)

What are the existing conditions these people have? *

Quit Smoking: 17 people, 36.96%
Pain: 11 people, 23.91%
Stress And Anxiety: 10 people, 21.74%
Migraine (headache): 8 people, 17.39%
Depression: 7 people, 15.22%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 6 people, 13.04%
Abdominal Discomfort: 5 people, 10.87%
Neuralgia (pain in one or more nerves): 5 people, 10.87%
Hypersensitivity: 5 people, 10.87%
Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 5 people, 10.87%

* Approximation only. Some reports may have incomplete information.

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