Nolvadex and Tykerb drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Nolvadex (tamoxifen citrate) and Tykerb (lapatinib ditosylate). Common drug interactions include spinal compression fracture among females.

The phase IV clinical study analyzes what interactions people have when they take Nolvadex and Tykerb. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Nolvadex?

Nolvadex has active ingredients of tamoxifen citrate. It is often used in breast cancer. eHealthMe is studying from 5,506 Nolvadex users. Check the latest studies of Nolvadex.

What is Tykerb?

Tykerb has active ingredients of lapatinib ditosylate. It is often used in breast cancer. eHealthMe is studying from 12,231 Tykerb users. Check the latest studies of Tykerb.

On Aug, 03, 2026

14 people who take Nolvadex and Tykerb together, and have interactions are studied.

What are the common drug interactions of Nolvadex and Tykerb, by gender? *:

female:

Spinal compression fracture (fracture due to spinal compression on bone)
Anaemia (lack of blood)
Atelectasis (partial or complete collapse of the lung)
Bone pain
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Cerebral atrophy (decrement in size of brain)
Cerebral haematoma (collection of blood in brain)
Cyst (a closed sac)
Dental caries
Diarrhoea

male:

n/a

What are the common drug interactions of Nolvadex and Tykerb, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Cardiomegaly (increased size of heart than normal)
Cardiotoxicity (damage to the heart muscle)
Cerebral atrophy (decrement in size of brain)
Cerebral haematoma (collection of blood in brain)
Confusional state
Contusion (a type of hematoma of tissue in which capillaries)
Cyst (a closed sac)
Dental caries
Diabetic neuropathy (neuropathic disorders that are associated with diabetes mellitus)
Diarrhoea

50-59:

Anaemia (lack of blood)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Arthralgia (joint pain)
Asthenia (weakness)
Atelectasis (partial or complete collapse of the lung)
Bone pain
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Cerebral atrophy (decrement in size of brain)
Cerebral haematoma (collection of blood in brain)

60+:

Anaemia (lack of blood)
Dermatitis acneiform (dermatoses including acne vulgaris, rosacea, folliculitis, and perioral dermatitis)
Liver disorder (liver diseases)
Neutropenia (an abnormally low number of neutrophils)
Pneumonitis (inflammation of the walls of the alveoli in the lungs)

What are the existing conditions these people have? *

Breast Cancer Metastatic: 3 people, 21.43%
Gastrointestinal Bacterial Infection (infection of the stomach and intestines caused by bacteria): 2 people, 14.29%
Depression: 2 people, 14.29%
Cancer Pain: 1 person, 7.14%
Constipation: 1 person, 7.14%
Cough: 1 person, 7.14%
Diarrhea: 1 person, 7.14%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 7.14%
Urinary Tract Infection: 1 person, 7.14%
Pelvic Pain: 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

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