Normodyne and Sublimaze drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Normodyne (labetalol hydrochloride) and Sublimaze (fentanyl citrate). Common drug interactions include fatigue among females and cellulitis of male external genital organ among males.

The phase IV clinical study analyzes what interactions people have when they take Normodyne and Sublimaze. It is created by eHealthMe based on reports of 23 people who take the same drugs from the FDA, and is updated regularly.

What is Normodyne?

Normodyne has active ingredients of labetalol hydrochloride. eHealthMe is studying from 858 Normodyne users. Check the latest studies of Normodyne.

What is Sublimaze?

Sublimaze has active ingredients of fentanyl citrate. eHealthMe is studying from 560 Sublimaze users. Check the latest studies of Sublimaze.

On Jul, 15, 2026

23 people who take Normodyne and Sublimaze together, and have interactions are studied.

Normodyne and Sublimaze drug interactions.

What are the common drug interactions of Normodyne and Sublimaze, by gender? *:

female:

Fatigue (feeling of tiredness)
Abdominal distension
Abdominal pain
Device dislocation
Dysmenorrhoea (painful menstruation)
Lymphocyte count decreased
Menorrhagia (an abnormally heavy bleeding and prolonged menstrual period at regular intervals)
Migraine (headache)
Uterine haemorrhage (uterine bleeding)
Stevens-johnson syndrome (an immune-complex-mediated hypersensitivity disorder. it ranges from mild skin and mucous membrane lesions to a severe)

male:

Cellulitis of male external genital organ (infection of male genitals soft tissue)
Scrotal abscess (pus in scrotum)
Bone density decreased
Cerebral haemorrhage (bleeding within the brain)
Depression
Emotional distress
Groin abscess (pus in groin)
Hip arthroplasty
Hyperkalaemia (damage to or disease of the kidney)
Hypoxia (low oxygen in tissues)

What are the common drug interactions of Normodyne and Sublimaze, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Anaemia (lack of blood)
Hip arthroplasty
Hyperkalaemia (damage to or disease of the kidney)
Hypoxia (low oxygen in tissues)
Leukopenia (less number of white blood cells in blood)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Weight bearing difficulty (difficulty due to weight of thigh fat deposition)

40-49:

Abdominal distension
Abdominal pain
Device dislocation
Dysmenorrhoea (painful menstruation)
Fatigue (feeling of tiredness)
Lymphocyte count decreased
Menorrhagia (an abnormally heavy bleeding and prolonged menstrual period at regular intervals)
Migraine (headache)
Uterine haemorrhage (uterine bleeding)
Haemangioma of skin (noncancerous, abnormally dense collections of dilated small blood vessels that may occur in the skin or internal organs)

50-59:

Chronic kidney disease
Cellulitis (infection under the skin)
Renal failure (kidney dysfunction)
Cellulitis of male external genital organ (infection of male genitals soft tissue)
Scrotal abscess (pus in scrotum)
Scrotal swelling
Abscess limb (limb infection)
Genital abscess (build up of pus in genital)
Necrotising fasciitis (an uncommon life-threatening soft-tissue infection)
Nephrogenic anaemia (anaemia due to kidney disease)

60+:

Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Fall
Chronic kidney disease
Genital abscess (build up of pus in genital)
Groin abscess (pus in groin)
Intracranial pressure increased (high pressure inside the skull and thus in the brain tissue and cerebrospinal fluid)
Necrotising fasciitis (an uncommon life-threatening soft-tissue infection)
Perineal abscess
Pulmonary congestion (congestion in the lungs)
Pulmonary oedema (fluid accumulation in the lungs)

What are the existing conditions these people have? *

Weight Decreased: 6 people, 26.09%
Pain: 6 people, 26.09%
Hypotension (abnormally low blood pressure): 6 people, 26.09%
Type 2 Diabetes: 6 people, 26.09%
Depression: 4 people, 17.39%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 13.04%
Migraine Without Aura (headache without neurological problems): 3 people, 13.04%
Hypertonic Bladder (bladder-storage function that causes a sudden urge to urinate): 3 people, 13.04%
Headache (pain in head): 3 people, 13.04%
Indigestion: 3 people, 13.04%

* Approximation only. Some reports may have incomplete information.

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