Norpramin and Zoloft drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Norpramin (desipramine hydrochloride) and Zoloft (sertraline hydrochloride). Common drug interactions include drug hypersensitivity among females and anaphylactic shock among males.

The phase IV clinical study analyzes what interactions people have when they take Norpramin and Zoloft. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Norpramin?

Norpramin has active ingredients of desipramine hydrochloride. It is often used in depression. eHealthMe is studying from 272 Norpramin users. Check the latest studies of Norpramin.

What is Zoloft?

Zoloft has active ingredients of sertraline hydrochloride. It is often used in depression. eHealthMe is studying from 138,798 Zoloft users. Check the latest studies of Zoloft.

On Jul, 15, 2026

20 people who take Norpramin and Zoloft together, and have interactions are studied.

What are the common drug interactions of Norpramin and Zoloft, by gender? *:

female:

Drug hypersensitivity
Insomnia (sleeplessness)
Abdominal pain
Anaphylactic shock (severe and rapid and sometimes fatal hypersensitivity reaction to a substance)
Anticonvulsant drug level below therapeutic
Drug ineffective
Lethargy (tiredness)
Nausea (feeling of having an urge to vomit)
Palpitations (feelings or sensations that your heart is pounding or racing)
Antinuclear antibody increased

male:

Anaphylactic shock (severe and rapid and sometimes fatal hypersensitivity reaction to a substance)
Cardiac failure congestive
Aphasia (damage to the parts of the brain that control language)
Asthenia (weakness)
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Drug ineffective
Drug level decreased
Haemorrhage (bleeding)
Headache (pain in head)

What are the common drug interactions of Norpramin and Zoloft, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Anticonvulsant drug level below therapeutic
Drug ineffective
Insomnia (sleeplessness)

40-49:

Antinuclear antibody increased
Antinuclear antibody positive
Aphasia (damage to the parts of the brain that control language)
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Drug level decreased
Insomnia (sleeplessness)
Psychotic disorder
Weight increased
Anticonvulsant drug level below therapeutic

50-59:

Abdominal pain
Anaphylactic shock (severe and rapid and sometimes fatal hypersensitivity reaction to a substance)
Lethargy (tiredness)
Nausea (feeling of having an urge to vomit)
Palpitations (feelings or sensations that your heart is pounding or racing)
Drug dependence
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Panic attack
Suicidal ideation

60+:

Drug hypersensitivity
Anaphylactic shock (severe and rapid and sometimes fatal hypersensitivity reaction to a substance)
Drug intolerance (drug sensitivity)
Thrombotic thrombocytopenic purpura (a rare blood disorder characterized by clotting in small blood vessels of the body)
Cardiac failure congestive
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Ejection fraction decreased (systolic heart failure)
Renal disorder (kidney disease)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)

What are the existing conditions these people have? *

Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 3 people, 15.00%
Post-Traumatic Stress Disorder: 2 people, 10.00%
Generalized Anxiety Disorder (excessive, uncontrollable, unexplained and often irrational worry): 2 people, 10.00%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 2 people, 10.00%
Temporal Lobe Epilepsy (a term that refers to a condition where seizures are generated in the portion of the brain called the temporal lobe): 1 person, 5.00%
Renal Cell Carcinoma (a kidney cancer): 1 person, 5.00%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 1 person, 5.00%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 5.00%
Drowsiness: 1 person, 5.00%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

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