Vytorin and Nexavar drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Vytorin (ezetimibe; simvastatin) and Nexavar (sorafenib tosylate). Common drug interactions include stomatitis among females and anorexia among males.

The phase IV clinical study analyzes what interactions people have when they take Vytorin and Nexavar. It is created by eHealthMe based on reports of 23 people who take the same drugs from the FDA, and is updated regularly.

What is Vytorin?

Vytorin has active ingredients of ezetimibe; simvastatin. It is often used in high blood cholesterol. eHealthMe is studying from 20,084 Vytorin users. Check the latest studies of Vytorin.

What is Nexavar?

Nexavar has active ingredients of sorafenib tosylate. It is often used in hepatocellular carcinoma. eHealthMe is studying from 23,250 Nexavar users. Check the latest studies of Nexavar.

On Jul, 15, 2026

23 people who take Vytorin and Nexavar together, and have interactions are studied.

What are the common drug interactions of Vytorin and Nexavar, by gender? *:

female:

Stomatitis (inflammation of mucous membrane of mouth)
Hypokalaemia (low potassium)
Abdominal abscess (collection of pus in abdomen)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Burning sensation
Diverticular perforation (serious gastrointestinal condition in which the intestine's walls are perforated)
Dysphagia (a condition in which swallowing is difficult or painful)
Hyperkeratosis (thickening of the outer layer of the skin)
Pneumoperitoneum (air or gas in the abdominal (peritoneal) cavity)
Skin exfoliation (removal of the oldest dead skin cells)

male:

Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Dyspnoea (difficult or laboured respiration)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Peroneal nerve palsy
Ventricular dysfunction (heart dysfunction)
Arthralgia (joint pain)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Chest pain
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Eating disorder

What are the common drug interactions of Vytorin and Nexavar, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Stomatitis (inflammation of mucous membrane of mouth)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Arthralgia (joint pain)
Diarrhoea
Hypokalaemia (low potassium)
Pain in extremity
Abdominal abscess (collection of pus in abdomen)
Burning sensation
Diverticular perforation (serious gastrointestinal condition in which the intestine's walls are perforated)
Dysphagia (a condition in which swallowing is difficult or painful)

60+:

Dyspnoea (difficult or laboured respiration)
Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
Ventricular dysfunction (heart dysfunction)
Chest pain
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Eructation (release of gas from the digestive tract)
Facial palsy (paralysis of face nerve)
Gastrointestinal perforation (hole in the digestive tract)
Haemoglobin decreased
Hypoxia (low oxygen in tissues)

What are the existing conditions these people have? *

Renal Cell Carcinoma Stage Unspecified (kidney cancer in unknown stage): 8 people, 34.78%
Renal Mass (mass in kidney): 2 people, 8.70%
Metastatic Renal Cell Carcinoma (spreadable kidney cell tumour): 2 people, 8.70%
Lung Cancer Metastatic (lung cancer spreads to other parts): 2 people, 8.70%

* Approximation only. Some reports may have incomplete information.

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