Norvir and Fosamax drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Norvir (ritonavir) and Fosamax (alendronate sodium). Common drug interactions include osteoarthritis among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Norvir and Fosamax. It is created by eHealthMe based on reports of 74 people who take the same drugs from the FDA, and is updated regularly.

What is Norvir?

Norvir has active ingredients of ritonavir. It is often used in hiv infection. eHealthMe is studying from 24,973 Norvir users. Check the latest studies of Norvir.

What is Fosamax?

Fosamax has active ingredients of alendronate sodium. It is often used in osteoporosis. eHealthMe is studying from 105,452 Fosamax users. Check the latest studies of Fosamax.



On Jul, 27, 2026

74 people who take Norvir and Fosamax together, and have interactions are studied.

Norvir and Fosamax drug interactions.

What are the common drug interactions of Norvir and Fosamax, by gender? *:

female:

  1. Osteoarthritis (a joint disease caused by cartilage loss in a joint)
  2. Renal failure (kidney dysfunction)
  3. Depression
  4. Gait disturbance
  5. Hip arthroplasty
  6. Multiple fractures
  7. Femoral neck fracture (neck of femur bone fracture)
  8. Femur fracture
  9. Joint injury
  10. Blood creatinine increased

male:

  1. Anxiety
  2. Pain
  3. Osteonecrosis (death of bone)
  4. Blood cholesterol increased
  5. Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
  6. Nephrolithiasis (calculi in the kidneys)
  7. Arthralgia (joint pain)
  8. Decreased activity
  9. Fracture
  10. Insomnia (sleeplessness)

What are the common drug interactions of Norvir and Fosamax, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

  1. Anhedonia (inability to experience pleasure from activities usually found enjoyable)
  2. Anxiety
  3. Bone density decreased
  4. Chronic kidney disease
  5. Emotional distress
  6. Lumbar vertebral fracture
  7. Pain
  8. Spinal compression fracture (fracture due to spinal compression on bone)
  9. Thoracic vertebral fracture

30-39:

  1. Pain
  2. Anxiety
  3. Depression
  4. Emotional distress
  5. Arthralgia (joint pain)
  6. Chronic kidney disease
  7. Fracture
  8. Fractured sacrum
  9. Gait disturbance
  10. Hip fracture

40-49:

  1. Nephrolithiasis (calculi in the kidneys)
  2. Blood creatinine increased
  3. Proteinuria (presence of protein in the urine)
  4. Diarrhoea
  5. Alanine aminotransferase increased
  6. Aspartate aminotransferase increased
  7. Blood bilirubin increased
  8. Disease progression
  9. Rash
  10. Skin reaction

50-59:

  1. Intervertebral disc disorder (spinal disc disorder)
  2. Intervertebral disc protrusion (spinal disc protrusion)
  3. Knee arthroplasty
  4. Lip exfoliation
  5. Multiple fractures
  6. Neuropathy peripheral (surface nerve damage)
  7. Osteoarthritis (a joint disease caused by cartilage loss in a joint)
  8. Palpitations (feelings or sensations that your heart is pounding or racing)
  9. Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
  10. Postoperative wound infection

60+:

  1. Emotional distress
  2. Pain
  3. Dysstasia (difficulty in standing)
  4. Fatigue (feeling of tiredness)
  5. Fracture
  6. Gait disturbance
  7. Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)
  8. Immobile (not moving)
  9. Impaired work ability
  10. Insomnia (sleeplessness)

What are the existing conditions these people have? *

  1. High Blood Pressure: 6 people, 8.11%
  2. Pain: 5 people, 6.76%
  3. Hyperlipidaemia (presence of excess lipids in the blood): 5 people, 6.76%
  4. Infection: 4 people, 5.41%
  5. Dizziness: 4 people, 5.41%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Norvir and Fosamax:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Norvir:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Fosamax:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Norvir and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Fosamax and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on ritonavir and alendronate sodium (the active ingredients of Norvir and Fosamax, respectively), and Norvir and Fosamax (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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