Nucynta er and Acetaminophen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Nucynta er (tapentadol hydrochloride) and Acetaminophen (acetaminophen). Common drug interactions include infusion related reaction among females and depressed level of consciousness among males.

The phase IV clinical study analyzes what interactions people have when they take Nucynta er and Acetaminophen. It is created by eHealthMe based on reports of 23 people who take the same drugs from the FDA, and is updated regularly.

What is Nucynta er?

Nucynta er has active ingredients of tapentadol hydrochloride. It is often used in pain. eHealthMe is studying from 2,508 Nucynta er users. Check the latest studies of Nucynta er.

What is Acetaminophen?

Acetaminophen has active ingredients of acetaminophen. It is often used in pain. eHealthMe is studying from 183,077 Acetaminophen users. Check the latest studies of Acetaminophen.

On Jul, 24, 2026

23 people who take Nucynta er and Acetaminophen together, and have interactions are studied.

Nucynta er and Acetaminophen drug interactions.

What are the common drug interactions of Nucynta Er and Acetaminophen, by gender? *:

female:

Infusion related reaction
Anaphylactic reaction (serious allergic reaction)
Cough
Demyelination (loss of the myelin covering of some nerve fibres resulting in their impaired function)
Hyperhidrosis (abnormally increased sweating)
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Therapeutic response decreased (less preventive response)
Arthropathy
Dyshidrotic eczema (skin condition in which blisters develop on the soles of your feet and/or the palms of hands)
Fall

male:

Depressed level of consciousness
Electrocardiogram qrs complex prolonged
Electrocardiogram qt prolonged
Respiratory depression (respiration has a rate below 12 breaths)
Aphasia (damage to the parts of the brain that control language)
Dysphagia (a condition in which swallowing is difficult or painful)
Muscle spasms (muscle contraction)
Swollen tongue (swelling of tongue)

What are the common drug interactions of Nucynta Er and Acetaminophen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Depressed level of consciousness
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Hypertension (high blood pressure)
Lethargy (tiredness)
Miosis (constriction of the pupil of the eye, resulting from a normal response to an increase in light)
Nystagmus (a condition of involuntary eye movement)
Renal disorder (kidney disease)
Respiratory depression (respiration has a rate below 12 breaths)
Serotonin syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time)
Suicide attempt

20-29:

Electrocardiogram qt prolonged
Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node)

30-39:

Nausea (feeling of having an urge to vomit)
Arthropathy
Dyshidrotic eczema (skin condition in which blisters develop on the soles of your feet and/or the palms of hands)
Nerve injury
Pneumonia
Rhinitis (a medical term for irritation and inflammation of the mucous membrane inside the nose)
Skin infection
Syncope (loss of consciousness with an inability to maintain postural tone)
Weight increased
Vomiting

40-49:

Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
Fall
Hypocalcaemia (levels of calcium in blood serum are abnormally low)
Hypotension (abnormally low blood pressure)
Pupillary reflex impaired
Tachycardia (a heart rate that exceeds the range of 100 beats/min)

50-59:

Pruritus (severe itching of the skin)
Depressed level of consciousness
Dry mouth
Dysphagia (a condition in which swallowing is difficult or painful)
Influenza like illness
Insomnia (sleeplessness)
Micturition disorder (disease of passing urine)
Muscle spasms (muscle contraction)
Paralysis
Pyrexia (fever)

60+:

n/a

What are the existing conditions these people have? *

Back Pain: 4 people, 17.39%
Immunodeficiency: 3 people, 13.04%
High Blood Pressure: 3 people, 13.04%
Urine Output Decreased: 2 people, 8.70%
Sleep Disorder: 2 people, 8.70%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 8.70%
Lung Cancer - Non-Small Cell (lung cancer): 2 people, 8.70%
Hypocalcaemia (levels of calcium in blood serum are abnormally low): 2 people, 8.70%
Hypersensitivity: 2 people, 8.70%
Hyperglycemia (high blood sugar): 2 people, 8.70%

* Approximation only. Some reports may have incomplete information.

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